BACKGROUND An intermediate endpoint is hypothesized to be in the middle of the causal sequence relating an independent variable to a dependent variable. The intermediate variable is also called a surrogate or mediating variable and the corresponding effect is called the mediated, surrogate endpoint, or intermediate endpoint effect. Clinical studies are often designed to change an intermediate o...

The presented tool uses a novel approach to explore and query a SPARQL endpoint. The tool is simple to use as a user needs only to enter an address of a SPARQL endpoint of one’s interest. The tool will extract and visualize graphically the data schema of the endpoint. The user will be able to overview the data schema and use it to construct a SPARQL query according to the data schema. The tool ...

We study the problem of finding a time-periodic solution to Euler–Bernoulli quasilinear equation describing vibrations beam subject stretching along horizontal axis. The boundary conditions correspond case rigidly clamped and elastically fixed endpoints. nonlinear term is power growth. Using variational method, we establish existence an unbounded sequence periodic solutions.

The utilisation of waste biomass in biodiesel production as a sustainable energy source can lead to the incorporation circular bioeconomy principles current economic systems. Herein, we synthesised magnetically recyclable solid acid catalyst for esterification date seed oil. catalysts possessed superparamagnetic behaviour and high saturation magnetisation, allowing them be easily separated from...

The growing convergence of Information Technology and Operational has enhanced communication visibility across power grids. This, coupled with the use Distributed Energy Resources in grids, grid capabilities while also creating a larger attack surface for malicious actors. A common protocol vulnerable to these attacks is IEC-61850 GOOSE due its low-latency requirements, multicast packet deliver...

Usually considered a background for experimental searches the hypothetical neutrinoless double beta decay process, two-neutrino nevertheless provides complementary probe of physics beyond Standard Model. In this paper we investigate how presence sterile neutrino, coupled to Model either via left-handed or right-handed current, affects energy distribution and angular correlation outgoing electro...

OBJECTIVES The purpose of the DEFINITIVE Ca(++) study was to evaluate the safety and effectiveness of directional atherectomy and distal embolic protection, used together to treat moderate to severely calcified femoropopliteal lesions. BACKGROUND Despite advances in endovascular treatment modalities, treatment of calcified lesions remains a challenge. METHODS A total of 133 subjects with 16...

The optimal design of phase II studies continues to be the subject of vigorous debate, especially studies of newer molecularly targeted agents. The observations that many new therapeutics "fail" in definitive phase III studies, coupled with the numbers of new agents to be tested as well as the increasing costs and complexity of clinical trials, further emphasize the critical importance of robus...

PURPOSE We have previously demonstrated associations between the urinary proteome profile and coronary artery disease (CAD) in cross-sectional studies. Here, we evaluate the potential of a urinary proteomic panel as a predictor of CAD in the hypertensive atherosclerotic cardiovascular disease (HACVD) substudy population of the Anglo-Scandinavian Cardiac Outcomes Trial study. EXPERIMENTAL DESI...

In this short paper, we present an architecture to deploy lightweight Semantic Sensor Networks easily based on widely available Android Devices. This approach essentially relies on deploying a SPARQL endpoint on the device, and federating queries to multiple devices to build Semantic Sensor Network applications.