The relationship between nitric oxide in exhaled air, levels of sputum eosinophils, sputum eosinophil cationic protein (ECP) and urinary eosinophil protein X (EPX) excretion has not yet been investigated in corticosteroid-dependent childhood asthma. Therefore, taking 25 children with stable asthma (mean age 11.2 yrs) treated with inhaled corticosteroids and nine nonatopic healthy control childr...

Few therapeutic alternatives to prednisone are available for severe, corticosteroid-resistant asthma. Injectable triamcinolone acetonide (TA) has been used in this type of asthma, although its use is controversial. TA shows considerable efficacy when compared with prednisone according to nearly all studies, although the majority do not provide a high level of evidence. The use of TA has been qu...

corticosteroids with that of orally or intravenously administered corticosteroids in the treatment of acute moderate/ severe asthma. Study Population. The 135 subjects were 6 to 17 years of age, with at least 1 previous episode of wheezing, and were recruited from 1 of 2 emergency centers (ECs) after presentation with acute asthma symptoms. Methods. Patients were randomized, after receiving an ...

BACKGROUND Internet-based self-management has shown to improve asthma control and asthma related quality of life, but the improvements were only marginally clinically relevant for the group as a whole. We hypothesized that self-management guided by weekly monitoring of asthma control tailors pharmacological therapy to individual needs and improves asthma control for patients with partly control...

corticosteroids with that of orally or intravenously administered corticosteroids in the treatment of acute moderate/ severe asthma. Study Population. The 135 subjects were 6 to 17 years of age, with at least 1 previous episode of wheezing, and were recruited from 1 of 2 emergency centers (ECs) after presentation with acute asthma symptoms. Methods. Patients were randomized, after receiving an ...

Rationale DPP-4 may regulate immunological pathways implicated in asthma. Assessing whether DPP-4 inhibitor (DPP-4i) use might affect asthma control is clinically important because DPP-4i use in type 2 diabetes mellitus management (T2DM) is increasing. This study evaluated associations between DPP-4i use and asthma control. Methods This was a retrospective, observational, matched cohort study...

OBJECTIVE Anti IgE treatment with omalizumab is efficacious in the treatment of patients suffering from allergic asthma, improving asthma control and improving quality of life. Furthermore, this approach could be beneficial for patients with concomitant atopic dermatitis. We assessed quality of life and asthma control in atopic patients with allergic asthma and concomitant atopic dermatitis ver...

The article by SZEFLER and LEUNG [1] on corticosteroid-resistant asthma is a useful and thorough review of a difficult topic. I am, however, concerned that three different conditions are becoming confused and this could have important implications for therapy. These conditions are: 1) difficult to control asthma; 2) corticosteroidresistant asthma; 3) other respiratory disease incorrectly diagno...