PURPOSE Under certain pathophysiologic conditions, the corneal endothelium can produce an abnormal posterior collagenous layer (PCL) that reduces light transmission. Previous studies suggest that formation of PCLs can result from transformation of endothelial cells to a proliferative myofibroblast phenotype. The purpose of this study was to determine the potential role of transforming growth fa...

The purpose of the study is to describe the values and distribution of corneal epithelium thickness (CET) in normal Chinese school-aged children, and to explore associated factors with CET. CET maps were measured by Fourier-domain optical coherence tomography (FD-OCT) in normal Chinese children aged 7 to 15 years old from two randomly selected schools in Shanghai, China. Children with normal in...

We describe an intrastromal corneal graft technique that uses femtosecond laser to create a desirable corneal lenticule with precise diameter, depth, and shape as well as an intra-stromal pocket in keratoconus patients. The technique seems to be a feasible and safe treatment option to treat keratoconic eyes with reference to the irregularity and instability of cornea. The technique can be perfo...

PURPOSE Tonometry is widely used as the main screening tool supporting glaucoma diagnosis. Still, its accuracy could be improved if full knowledge about the variation of the corneal biomechanical properties was available. In this study, Optical Coherence Tomography (OCT) speckle statistics are used to infer the organisation of the corneal micro-structure and hence, to analyse its influence on i...

The rabbit corneal endothelium phagocytized polystyrene spheres 0.5 Mm in diameter. After phagocytizing spheres, the endothelium degenerated, and lost from the Descemet's membrane. Lysosomal enzyme activities of the endotheliumDescemet's membrane complex, such as acid phosphatase, /?-glucuronidase and N-acetyl-/?-D-glucosaminidase, were assayed and the total activities per microgram DNA were al...

PURPOSE The purpose of the current study was to investigate the effect of topical administration of KH906 on corneal neovascularization (NV). METHODS To induce corneal neovascularization, chemical cauterization of the corneas of the right eyes of forty-eight New Zealand white rabbits was performed by touching the central cornea with an 8-mm-diameter NaOH-soaked Whatman filter paper for 60 s. ...

Purpose: To study the effect of phototherapeutic keratectomy (PTK) in the treatment of various superficial corneal pathologies. Methods: We performed a nonrandomized, prospective study on patients who presented with superficial corneal disease and/or poor vision. Fifty eyes were included; recurrent corneal erosion (RCE): 25 eyes, Salzmann’s nodular degeneration: 9 eyes, spheroidal degeneration:...

OBJECTIVES To evaluate corneal densitometry and anterior segment parameters of rheumatoid arthritis (RA) patients and compare these results with those of age-matched healthy control subjects. MATERIALS AND METHODS Anterior segment parameters and corneal densitometry of patients with RA and healthy control subjects were assessed by Scheimpflug corneal topography. For densitometry analysis, the...