INTRODUCTION A wide variety of fractionation schedules have been employed for the treatment of early glottic cancer. The aim is to report our 10-year experience of using hypofractionated radiotherapy with 55Gy in 20 fractions at 2.75Gy per fraction. METHODS Patients treated between 2004 and 2013 with definitive radiotherapy to a dose of 55Gy in 20 fractions over 4 weeks for T1/2 N0 squamous c...

The first spinal commissurotomy was performed by Armour and reported in 1927. The patient, suffering from tabetic gastric pain, died post-operatively. Putnam (1934) devised a similar procedure independently and advocated it for intractable pain in the arms and shoulders. The operation aimed at interrupting the decussating fibres passing to the spinothalamic tracts and, since the decussation was...

STUDY DESIGN Retrospective study. PURPOSE To obtain information useful in establishing treatment guidelines by evaluating baseline clinical features and treatment outcomes of patients with spinal cord astrocytoma (SCA). OVERVIEW OF LITERATURE The optimal management of SCA remains controversial, and there are no standard guidelines. METHODS The study included 20 patients with low-grade and...

BACKGROUND No cure is available for human spinal cord injury. Cell elimination by localized radiation therapy that is timed within 2-3 weeks postinjury can facilitate repair of structure and function in transected rat spinal cord. In pilot studies in contusion spinal cord injury, a model similar to crush/fracture injury in human, we did not observe the expected beneficial effects of radiation t...

Hydromyelia is a disorder in which the central canal of the spinal cord is distended with spinal fluid . The hydromyelia may be segmental, polysegmental, or holocord [1]. Many surgical techniques have been employed for the decompression of symptomatic hydromyelia, including hydromyelio-subarachnoid or hydromyelio-peritoneal shunts, aspiration of the syrinx cavity, terminal ventriculostomy, and ...

of some presumed mechanisms for pain in contracting muscle, the book becomes intensely practical, dealing with such subjects as percutaneous stereotactic radiofrequency trigeminal tractotomy, percutaneous stereotactic cingulumotomy, transcutaneous "electrical cordotomy," and research dealing with these modes of therapy. Again, a highly conservative tone is maintained throughout, and as many dat...

This book is published as one of a series entitled Foundations ofNeurological Surgery and is a clearly produced volume. The early sections on laser types and laser physics read easily and are well illustrated, but the one which follows on the interaction oflaser light with neural tissue is a little less clear but quite comprehensive. The section on benign supratentorial tumours is more of a mat...

OBJECTIVES The objective of our study was to test the hypothesis that in utero repair of surgically created spina bifida in a sheep model using cryopreserved human umbilical cord (HUC) patch improves neurological outcome. METHODS Spina bifida with myelotomy was surgically created in timed pregnant ewes at gestational day (GD) 75. The fetuses were randomly assigned to unrepaired versus HUC and...

BACKGROUND Radiofrequency (RF) subthalamotomies have been proposed since the 1960s to treat patients suffering from Parkinson's disease (PD). Recently, the magnetic resonance (MR)-guided focused ultrasound technology (MRgFUS) offers the possibility to perform subthalamic thermocoagulations with reduced risks and optimized accuracy. We describe here the initial results of the MRgFUS pallidothala...

A limited midline myelotomy at T10 can relieve pelvic cancer pain in patients. This observation is explainable in light of strong evidence in support of the existence of a visceral pain pathway that ascends in the dorsal column (DC) of the spinal cord. In rats and monkeys, responses of neurons in the ventral posterolateral thalamic nucleus to noxious colorectal distention are dramatically reduc...