The prion protein (PrP) is responsible for a group of neurodegenerative diseases called the transmissible spongiform encephalopathies. The normal function of PrP has not yet been discovered, but indirect evidence suggests a linkage to its ability to bind copper. In this article, low-copper-concentration bindings of Cu(2+) to PrP are investigated by using a recently developed hybrid density func...

in this study, synthesis of copper nanoparticles and effect of the reaction conditions on the particle size were investigated. the copper nanoparticles were synthesized and stabilized in a narrow temperature range in the presence of polyvinylpyrrolidone under nitrogen atmosphere. reaction temperature and concentration ratio of the reducing agent to the precursor (r/p) as two main conditions i...

Extraction of nickel and its co-extraction with copper from ammoniacal media into emulsion liquid membrane systems (ELMs) was investigated using LIX 84I as the carrier. Measurement of the solute stripped in the internal phase of emulsion opened a new dimension in the study of the ELM extraction processes. The effect of operating parameters such as feed pH, initial feed concentration, and treat ...

The present study was conducted with the objective to the iron, copper and zinc variations in serum of Nili-Ravi buffaloes during pre and post partum periods determine. The study was carried out on 35 pregnant Nili-Ravi buffaloes during June 2008 to October 2008 at Buffalo Research Institute, Pattoki, District Kasur. Blood samples were taken from these buffaloes during three, two and one week b...

Lobsters were fed cadmium-rich oysters for 28 days, and the induction of cadmium metallothionein and its relation to concentrations of cadmium, copper, and zinc in the digestive gland and gills was determined. A portion of the tissues also was retained for determining the cytosolic distribution of these metals by gel filtration and ion-exchange chromatography. The digestive gland contained a ma...

concentration of heavy metals in aquatic ecosystems is considered as an important environmantal issue. in this study, the namrood river located in firoozkooh (tehran province, iran) was assessed for the existence of heavy metals. the namrood river is situated by the main road being by pollutants from tourism and recreational centers, gas stations, sewage of villages, agricultural wastewater and...

The Atp7b protein is a copper-transporting ATPase expressed predominantly in the liver and to a lesser extent in most other tissues. Mutations in the ATP7B gene lead to Wilson disease, a copper toxicity disorder characterized by dramatic build-up of intracellular hepatic copper with subsequent hepatic and neuro-logical abnormalities. Using homologous recombination to disrupt the normal translat...

OBJECTIVE Copper deficiency has been reported to cause hematological disorders. However, its clinical and hematological characteristics are not fully understood. Therefore, we investigated bedridden patients suffering from copper deficiency and tried to clarify the clinical features of hematological disorders caused by this condition. PATIENTS AND METHODS Five patients with typical copper def...

A new vertical mesh transfer (VMT) technique has been developed to facilitate the rapid isolation of plant metal-tolerance mutants. l h e technique i s quantitative, allowing comparisons of the growth responses of different strains or ecotypes. Using the VMT technique, we have characterized the dose responses of 1 O ecotypes of Arabidopsis fhaliana to Cuz+, Znz+, NiZ+, Cr3+, Cd2+, and AI3+. Eco...

background: the aim of this study was to evaluate copper status in women with preeclampsia. materials and methods: sixty preeclamptic, sixty normotensive pregnant and sixty healthy nonpregnant women were enrolled in a cross sectional study. the 24-hour urine copper was compared among the women. results: there was significant difference in the copper concentration of 24-hour urine among the thre...