Multiple cooperating mutations that deregulate different signaling pathways are required to induce cancer. Identifying these cooperating mutations is a prerequisite for developing better combinatorial therapies for treating cancer. Here we show that cooperating cancer mutations can be identified through oncogenic-retrovirus-induced insertional mutagenesis. Among 13 myeloid leukemias induced by ...

This article presents case studies detailing the learning trajectories of two physical education (cooperating) teachers as they strive to establish and maintain their identity as competent and confident supervisors to pre-service teachers on school placement. The cooperating teachers who participated in the study share their experiences in attempting to construct a professional identity within ...

This paper investigates the power of the stream X-machines based on cooperating distributed grammar systems which replaces relations by functions. The case of regular rules is considered. The deterministic case is introduced in order to allow the application of some already developed testing strategies. Some conditions for getting equivalent stream X-machines in the = 1 derivation mode are stud...

Necessary and sufficient conditions for the commutativity of linear time-varying systems are derived in the case of nonzero initial conditions. It is shown that some commutative class of linear time-varying systems may not commute with arbitrary initial conditions. In this respect, commutativity of Euler differential systems is investigated. Explicit commutativity conditions for the fifth-order...

EEcient reasoning about temporal constraints over nonlin-ear time models is vital in numerous application areas, such as planning, distributed systems and cooperating agents. We identify all tractable subclasses of the point algebra for partially-ordered time and examine one large, nontrivial tractable subclass of the point algebra for branching time.

E cient reasoning about temporal constraints over nonlinear time models is vital in numerous application areas, such as planning, distributed systems and cooperating agents. We give a total classi cation of tractable classes for the point algebra over partially ordered time and examine one large tractable subclass of the point algebra over branching time.

‘Computer-Supported Cooperative Work’ (CSCW) is a young, interdisciplinary research area considering applications with strong demands on multiple fields of computer technology, e.g., distributed systems and networks or multi-media systems. In this paper, we will be focusing on the information-sharing and the corresponding activity-control aspect. Here, the conventional transaction concept of da...

It is known that cooperating distributed systems (CD-systems) of stateless deterministic restarting automata with window size 1 accept a class of semi-linear languages that properly includes all rational trace languages. Although the component automata of such a CD-system are all deterministic, the CD-system itself is not, as in each of its computations, the initial component and the successor ...

Most psychological research on reinforcement learning has depicted two systems locked in battle for control of behavior: a flexible but computationally expensive “model-based” system and an inflexible but cheap “model-free” system. However, the complete picture is more complex, with the two systems cooperating in myriad ways. We focus on two issues at the frontier of this research program. Firs...

Flexible planning and control of a factory requires concepts for the representation of the local and global knowledge of the autonomous systems working in teams. Therefore, we developed a distributed real-time knowledge base that facilitates teamwork of autonomous systems in exible manufacturing environments. The knowledge base consists of several local knowledge bases cooperating with each oth...