BACKGROUND Phenoxodiol is a novel isoflavone currently being studied in clinical trials for the treatment of cancer. This study reports the pharmacokinetics of phenoxodiol in patients with cancer. METHODS The pharmacokinetics of phenoxodiol was studied following a single intravenous (iv) bolus dose and during a continuous intravenous infusion. Three men with prostate cancer and 3 women with b...

Long term continuous hepatic artery infusion of FUDR was carried out in 34 rats. In the animals who received a constant infusion schedule of 15 mg/kg/day all died of toxicity with a mean survival of 9.3 days. If the pattern of the continuous infusion was changed so that over 60% of the infusion was given during the hours of 3pm to 9pm than all of the animals survived the 14 day infusion. If the...

The worrisome increase in Gram-negative bacteria with borderline susceptibility to carbapenems and of carbapenemase-producing Enterobacteriaceae has significantly undermined their efficacy. Continuous infusion may be the best way to maximize the time-dependent activity of meropenem. The aim of this study was to create dosing nomograms in relation to different creatinine clearance (CL(Cr)) estim...

dministering cancer chemotherapy by continuous intravenous infusion (CIVI) has several potential advantages over administration by short intravenous infusions1 and has been facilitated by the development of portable infusion pumps.2 In a study by Wilson et al.,3 the EPOCH regimen—etoposide, prednisone, vincristine, cylophosphamide, and doxorubicin—was shown to be highly effective and well toler...

The intraocular pressure was measured at 5-minute intervals with a Perkins applanation tonometer in 5 patients undergoing routine dacryocystorhinostomy under low-tension anaesthesia with a continuous intravenous infusion of trimetaphan (Arfonad), the systolic pressure being maintained at 66 mmHg. Twelve patients undergoing cataract surgery under the same premedication and anaesthesia but in who...

Warfarin requirements are lower in the Chinese, but it is not known if this applies to heparin. We investigated the optimal dose for heparin therapy in Chinese patients, and to assess relationship between i.v. heparin dosage and anticoagulation efficacy. One hundred Chinese patients requiring intravenous heparin therapy were given an initial bolus followed by continuous intravenous infusion. Th...

Thirty-two consecutive children aged 0-18 years with VTE treated with LMWH administered as a continuous infusion (CI) were identified at the Children's University Hospital Brno. The treatment led to at least partial resolution of the thrombus within two weeks in 85% of patients. There were no adverse events or increased bleeding reported in any patients. No recurrences were observed during a fo...

This study describes efficacy of continuous infusion of bumetanide in severe congestive heart failure (CHF) associated with severe renal failure. Renal failure progresses as CHF advances. Renin-angiotensin inhibitor drugs consisting of angiotensin converting enzyme inhibitor and angiotensin receptor blocker are main stay of therapy in CHF. These drugs aggravate renal failure, decrease urine out...

BACKGROUND Remifentanil is an effective drug for protecting against adverse haemodynamic responses to tracheal intubation. We compared the haemodynamic responses during anaesthesia induction between continuous intravenous (IV) infusion and two bolus injections of remifentanil. METHODS This prospective, randomised, open-label, single-centre study included patients with American Society of Anes...

The objective of the present investigation was to characterize the pharmacodynamic interaction between the synthetic neuroactive steroid alphaxalone and the benzodiazepine midazolam. The time course of the electroencephalographic (EEG) effect (11.5-30 Hz) was determined in rats in conjunction with plasma concentrations. Alphaxalone was administered as a continuous intravenous infusion of 0, 1.2...