The cytokinetic response of a human colon carcinoma cell line to cis-dichlorodiammineplatinum(II) was investigated using flow cytometry of DNA content, autoradiography after pulse and continuous tritiated thymidine exposure, and mitotic accumulation after continuous Colcemid treatment. With increasing concentration and exposure time, cis-dichlorodiammineplatinum(II) delayed and then blocked cyc...

Continuous exposure to nicotine causes behavioral choice to be modified by dopamine to become rigid, resulting in addiction. In this work, a computational model for nicotine addiction is proposed and the proposed model captures the effect of continuous nicotine exposure in becoming addict through reinforcement learning. The computational model is composed of three subsystems each corresponding ...

background : substantial evidence indicates that exposure to electromagnetic fields (emf) above certain levels can affect human health through triggering some biological responses. according to who, short-term exposure to emf at the levels present in the home/environment do not cause any apparent detrimental effects in healthy individuals. however, now, there is a debate on whether long-term ex...

Variation in the odds ratio (OR) resulting from selection of cutoffs for categorizing continuous variables is rarely discussed. We present results for the effect of varying cutoffs used to categorize a mismeasured exposure in a simulated population in the context of autism spectrum disorders research. Simulated cohorts were created with three distinct exposure-outcome curves and three measureme...

OBJECTIVE To determine whether fluoridation influences bone mineral density and fractures in older women. DESIGN Multicentre prospective study on risk factors for osteoporosis and fractures. SETTING Four community based centres in the United States. PARTICIPANTS 9704 ambulatory women without bilateral hip replacements enrolled during 1986-8; 7129 provided information on exposure to fluori...

BACKGROUND It has been hypothesized in the literature that exposure to extremely low frequency electromagnetic fields (50 or 60 Hz) may lead to human health effects such as childhood leukemia or brain tumors. In a previous study investigating multiple types of cells from brain and kidney of the mouse (Acta Neuropathologica 2004; 107: 257-264), we found increased unrepaired nuclear DNA single st...

Caspofungin pharmacokinetics was assessed in 27 critically ill patients, including 7 on continuous venovenous hemofiltration (CVVH), 8 on continuous venovenous hemodialysis (CVVHD), and 13 not requiring continuous renal replacement therapy (CRRT). Caspofungin exposure during CRRT was very similar to that of the control group and comparable to that in healthy volunteers. Caspofungin clearance by...

In this study, immobilization of partially purified almond (Amygdalus communis) β-galactosidase on Con A layered calcium alginate-cellulose beads was investigated. Immobilized β-galactosidase retained 72% of theinitial activity after crosslinking by glutaraldehyde. Both soluble and immobilized enzyme exhibited the samepH and temperature optima at pH 5.5 and 50ºC, respectively. Howev...

We administered cis-diamminedichloroplatinum(II), 30 my/iir/day for 5 days by continuous infusion to six patients with head and neck cancer, and compared the total and filterable plasma concentrations of platinum, and toxic effects, with those observed in five additional patients who received the same dose and schedule of cij-diamminedichloroplatinum(II) by intermittent bolus. In the continuous...