BACKGROUND During the FMD outbreak in Ireland and the UK in 2001, there was significant uncertainty amongstveterinary practitioners and government veterinary inspectors surrounding the clinical diagnosis of FMD insheep. This situation was complicated by reports of idiopathic oral ulcers that closely resembled FMD ongross appearance which at that time were referred to as ovine mouth and gum obsc...

Ecthyma gangrenosum (EG) is a well-described skin lesion classically associated with Pseudomonas septicemia in immunocompromised patients, but may also be caused by other bacterial and fungal organisms [1]. The lesions characteristically appear as small indurated papulovesicles progressing rapidly to necrotic ulcers with surrounding erythema and a central black eschar [2]. Ecthyma gangrenosum i...

The viral three-prime repair exonuclease (v-trex) gene of the Anticarsia gemmatalis multicapsid nucleopolyhedrovirus (AgMNPV) is the first baculovirus gene to be described with significant homology to a 3' exonuclease. v-trex is an early gene that is expressed by AgMNPV from 3 h post-infection. In the present study, the AgMNPV v-trex ORF was cloned into the baculovirus Autographa californica mu...

Sir, Pustular bacterid (PB) is a pustular disorder of the hands and/or feet. It was first described by Andrews and co-workers (1, 2). There is controversy as to whether PB is a separate disease or is a variant of psoriasis pustulosa palmaris et plantaris (PPP). We describe here a case of PB in a patient with ankylosing spondylitis (AS). This is the first report of PB associated with AS and supp...

UNLABELLED Oxycodone hydrochloride controlled-release, also known as extended-release oxycodone (ER oxycodone), was reformulated with physicochemical barriers to crushing and dissolving intended to reduce abuse through nonoral routes of administration (ROAs) that require tampering (eg, injecting and snorting). Manufacturer shipments of original ER oxycodone (OC) stopped on August 5, 2010, and r...

We have cloned, sequenced, and characterized the complete genome of a novel human papillomavirus (HPV), candHPV62. During cloning, 2 candHPV62 viral isolates were recovered from a single cervical sample; 1 had all anticipated HPV open-reading frames (ORFs) intact, whereas the other exhibited an E1 frame-shift mutation. Further experiments indicated that the 2 strains were equivalent in abundanc...

This paper provides an analytical framework and uses data from the U.S. and Germany to test for the existence of contagious presenteeism and negative externalities in sick leave insurance. The first part exploits high-frequency Google Flu data and the staggered implementation of U.S. sick pay mandates to show in a reduced-form framework that population-level influenzalike disease rates decrease...

BACKGROUND Pseudomonas oryzihabitans is a Pseudomonas bacterial organism rarely implicated in human infections. The bacterium has been isolated in a few reported cases of neurosurgical infections and patients with end-stage cirrhosis, sickle cell disease, and community-acquired urinary tract infections. Limited information exists in developing countries, however, because of the lack of advanced...

Culture affects almost every aspect of an individual's life, from social and familial behavior and values, to motivations and identity. Traditional methods of economic development have not included a consideration of cultural influences at the initial data collection and analysis stages and consequently the role and impact of culture is not properly reflected in subsequent economic development ...