BACKGROUND The purpose of this study was to assess whether differences in central corneal dendritic immune cell densities associated with combinations of soft contact lenses and lens care solutions could be detected by in vivo confocal microscopy. METHODS Participants were adults naïve to contact lens wear (n = 10) or who wore soft contact lenses habitually on a daily-wear schedule (n = 38) o...

OBJECTIVE To determine the efficacy of argon laser punctal stenosis inpatients with contact lens-induced dry eyes. METHODS A retrospective review of 25 eyes of 13 patients who underwent argon laser punctal stenosis to improve their contact lens intolerance was performed. The mean age was 31 (range, 21-52) years and 11 patients (85%) were women. The mean Schirmer I test was 15.2 (range, 3-35)....

BACKGROUND The aim of this study was to investigate deposit buildup on prosthetic eyes and the implications for conjunctival inflammation and discharge. METHODS Forty-three prosthetic eye wearers participated in the study. Twenty-three had their prostheses polished normally before being worn continuously for 2 weeks. After this time, surface deposits were stained, photographed, and graded. Th...

PURPOSE Many soft contact lens wearers have symptoms or signs that compromise successful lens wear. This study estimated the prevalence of problems in current wearers of soft contact lenses and tested the effect of refitting patients with senofilcon A silicone hydrogel lenses (ACUVUE Oasys). METHODS Prevalence was estimated from 1,092 current lens wearers for frequent or constant discomfort o...

PURPOSE To assess the relationship between the thinnest corneal location and the steepest and maximum elevation corneal locations in subjects with keratoconus and the effect of gas permeable contact lens wear on the location of these points. METHODS Sixty-one consecutive subjects (98 eyes) with keratoconus. Thirty-one (49 eyes) and 30 (49 eyes) subjects were gas permeable contact lens (CL-W) ...

PURPOSE To determine changes in physicochemical surface properties of contact lenses (CLs) during daily wear and effects of lens wear on adhesion of a Pseudomonas aeruginosa strain from a patient with CL-related keratitis. METHODS Ten new CL wearers used ionic, etafilcon A lenses with 58% water on both eyes for approximately 10 hours each day during 10 and 50 days. All lenses were treated dai...

PURPOSE Contact lens wear predisposes to Pseudomonas aeruginosa keratitis, but the mechanisms involved remain unclear. An in vivo model was used to study lens inoculation conditions enabling disease. METHODS Custom-made hydrogel contact lenses were fitted to rats after incubation in P. aeruginosa approximately 10(11) cfu/mL (3 hours) or approximately 10(3) cfu/mL (24 hours). Another group was...

purpose: to determine the effect of using rigid gas permeable (rgp) contact lenses in improvement of involuntary eye movements and visual functions in hyperopic astigmatism patients with congenital nystagmus. methods: this prospective interventional case series study was conducted on patients with congenital nystagmus and hyperopia equal or more than +0.5 d and astigmatism more than -1 d, who w...

The deposition of biological material (biofouling) onto polymeric contact lenses is thought to be a major contributor to lens discomfort and hence discontinuation of wear. We describe a method to characterize lipid deposits directly from worn contact lenses utilizing liquid extraction surface analysis coupled to tandem mass spectrometry (LESA-MS/MS). This technique effected facile and reproduci...

OBJECTIVE The primary aim of the Berkeley Contact Lens Extended Wear Study (CLEWS) was to test the hypotheses that extended wear of rigid gas-permeable (RGP) contact lenses with greater oxygen permeability (Dk) reduces the incidence of contact lens-associated keratopathy (CLAK) and increases the survival rate in RGP extended wear (EW). In this article we describe the clinical trial design in de...