In mammals, the SET1 family of lysine methyltransferases (KMTs), which includes MLL1-5, SET1A and SET1B, catalyzes the methylation of lysine-4 (Lys-4) on histone H3. Recent reports have demonstrated that a three-subunit complex composed of WD-repeat protein-5 (WDR5), retinoblastoma-binding protein-5 (RbBP5) and absent, small, homeotic disks-2-like (ASH2L) stimulates the methyltransferase activi...

Scaffolding serves as one construction trade with high importance. However, scaffolding suffers from low productivity and cost in Australia. Activity Analysis is a continuous procedure of assessing improving the amount time that craft workers spend on single trade, which functional method for monitoring onsite operation analyzing conditions causing delays or decline. Workface assessment an init...

Molecular dynamics simulation of an atom-resolved bacteriophage P22 capsid model is used to delineate the underlying mechanism of early stage P22 self-assembly. A dimer formed by the C-terminal fragment of scaffolding protein with a new conformation is demonstrated to catalyze capsomer (hexamer and pentamer) aggregation efficiently. Effects of scaffolding protein/coat protein binding patterns a...

Scaffolding students in open-ended learning environments (OELEs) is a difficult challenge. The open-ended nature of OELEs allows students to simultaneously pursue, modify, and abandon any of a large number of both short-term and long-term approaches to completing their tasks. To overcome these challenges, we have recently developed coherence analysis, which focuses on students’ ability to inter...

Purpose Statistics show that the construction sector has second-highest number of accident cases in Malaysia. A total 100, 000 workers suffer from work-related bad health each year. Scaffolding accidents are second cause on sites. Therefore, this present research provided answers to following questions: (1) what causes scaffolding and (2) possible measures reduce accidents? Design/methodology/a...