نتایج جستجو برای: conjugates gradient method
تعداد نتایج: 1733637 فیلتر نتایج به سال:
Over the last 3 decades, electrochemistry (EC) has been successfully applied in phase I and II metabolism simulation studies. The electrochemically generated metabolite-like oxidation products can react with selected reagents to form conjugates. During conjugate formation, generation of isomeric compounds is possible. Such conjugates are often separated by high-performance liquid chromatography...
We describe maleic-acid derivatives as robust cysteine-selective reagents for protein labelling with comparable kinetics and superior stability relative to maleimides. Diamide amido-ester proved be efficient protein-labelling species a common mechanism in which spontaneous cyclization occurs upon addition cysteine. Introduction of chlorine atoms their structures triggers ring hydrolysis or furt...
OBJECTIVES To develop new HIV-1 fusion inhibitors with improved antiviral activities and resistance profiles, we designed two categories of artificial peptides, each containing four heptad repeats (m4HR) conjugated with a pocket-specific small molecule (pssm) or pssm and cholesterol (chol), designated pssm-m4HR or pssm-m4HR-chol, respectively, and tested their anti-HIV-1 activity. METHODS We ...
this research was conducted in two protect and destroy region in the middle zagros, in illam province. in order to identification of ecological species group and evaluate density of regeneration, effect of many factors such as protection, vegetation, physiographic factors, physical and chemical properties of soil in study locations were studied. to achieve these purpose number of 54 plots using...
Background and purpose: Bombesin shows very high-affinity for the Gasterin releasing peptide (GRP) receptors which are over expressed in different human tumors such as breast and prostate. The aim of this study was to identify a new bombesin derivative labeled with 99mTc via HYNIC that might be used as a noninvasive tool for diagnosis of GRP receptor expressing tumors. Materials and methods: P...
In this article a preconditioned version of the Delayed Weighted Gradient Method (DWGM) is presented and analyzed. addition to convergence, some nice properties as A- orthogonality current transformed gradient with all previous vectors well finite convergence are demonstrated. Numerical experimentation also offered, exposing benefits preconditioning.
The Discontinuous Petrov-Galerkin (DPG) method for high frequency wave propagation problems is discussed. The DPG method offers uniform pre-asymptotic stability for any wavenumber. This allows for a fully automatic adaptive hp algorithm, that can start from very coarse meshes. Moreover DPG always delivers a Hermitian positive definite system, suggesting the use of the Conjugate Gradient algorit...
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