→ R n is continuous.Throughout this paper, this problem corresponds to optimality condition of a certain problem of minimizing f : Rn → R which may be not easy to calculate or cannot be expressed as elementary functions. When the dimension n is large, conjugate gradient methods can be efficient to solve problem (1). For any given starting point x 0 ∈ R , a sequence {x k } is generated by the fo...

3D object detection in autonomous driving aims to reason “what” and “where” the objects of interest present a world. Following conventional wisdom previous 2D detection, existing methods often adopt canonical Cartesian coordinate system with perpendicular axis. However, we conjugate that this does not fit nature ego car’s perspective, as each onboard camera perceives world shape wedge intrinsic...

OBJECTIVE Streptococcus pneumoniae is a common pathogenic cause of pediatric infections. This study investigated the serotype distribution, antimicrobial susceptibility, and molecular epidemiology of pneumococci before the introduction of conjugate vaccines in Shanghai, China. METHODS A total of 284 clinical pneumococcal isolates (270, 5, 4,3, and 2 of which were isolated from sputum, broncho...

BACKGROUND The success of 7-valent pneumococcal conjugate vaccination (PCV-7) introduced to the US childhood immunization schedule in 2000 was partially offset by increases in invasive pneumococcal disease (IPD) and pneumococcal carriage due to non-vaccine serotypes, in particular 19A, in the years that followed. A 13-valent conjugate vaccine (PCV-13) was introduced in 2010. As part of an ongoi...

In this paper, we present new variants of global bi-conjugate gradient (Gl-BiCG) and global bi-conjugate residual (Gl-BiCR) methods for solving nonsymmetric linear systems with multiple right-hand sides. These methods are based on global oblique projections of the initial residual onto a matrix Krylov subspace. It is shown that these new algorithms converge faster and more smoothly than the Gl-...

While it is generally accepted that the stability of a static memory pattern corresponds to a certain point attractor in the dynamics of the underlying neural network, when temporal order is introduced and a sequence of memory patterns need to be retrieved successively in continuous time, it becomes less clear what general method should be used to decide whether the transient dynamics is robust...

Treatment methods for breast cancer are not specific and each one has its own drawbacks. For this reason, scientists are seeking ways in which specifically affect cancer cells. Photothermal therapy is a method that uses near-infrared (NIR) laser energy to create sufficient heat to destroy cancer cells. In this study, the photothermal effect of gold nanorods (GNRs) was investigated for breast ca...

Treatment methods for breast cancer are not specific and each one has its own drawbacks. For this reason, scientists are seeking ways in which specifically affect cancer cells. Photothermal therapy is a method that uses near-infrared (NIR) laser energy to create sufficient heat to destroy cancer cells. In this study, the photothermal effect of gold nanorods (GNRs) was investigated for breast ca...

SPACE INVADERS: Organometallic fragments such as the ferrocenyl group (shown in red in the picture) help to enhance cellular entry of NLS peptides. Eventually, these nontoxic conjugates find their way to the cellular nucleus as shown by fluorescence microscopy studies in this work. Intracellular delivery to biomolecular targets is still a major challenge in molecular and cell biology. We recent...

Abstract. We consider methods for large-scale unconstrained minimization based on finding an approximate minimizer of a quadratic function subject to a two-norm trust-region inequality constraint. The Steihaug-Toint method uses the conjugate-gradient algorithm to minimize the quadratic over a sequence of expanding subspaces until the iterates either converge to an interior point or cross the co...