${\mathrm{Cu}}_{2}{\mathrm{OSeO}}_{3}$ represents a unique example in the family of B20 cubic helimagnets with tilted spiral and low-temperature skyrmion phase arising for magnetic fields applied along easy crystallographic $\ensuremath{\langle}100\ensuremath{\rangle}$ axes. Although stabilization mechanism these phases can be accounted by anisotropy, nucleation process is still an open questio...

We study the force vs extension behaviour of a helical spring made of a thin torsionally-stiff anisotropic elastic rod. Our focus is on springs of very low helical pitch. For certain parameters of the problem such a spring is found not to unwind when pulled but rather to form hockles that pop-out one by one and lead to a highly non-monotonic force-extension curve. Between abrupt loop pop-outs t...

MOTIVATION The coiled coil is a ubiquitous α-helical protein structure domain that directs and facilitates protein-protein interactions in a wide variety of biological processes. At the protein-sequence level, coiled coils are quite straightforward and readily recognized via the conspicuous heptad repeats of hydrophobic and polar residues. However, structurally they are more complicated, existi...

The neurotoxicity of Aβ is associated with the formation of free radical by interacting with redox active metals such as Cu(2+). However, the relationship between ion-interaction, ion-driven free radical formation, and Aβ conformation remains to be further elucidated. In the present study, we investigated the correlation of Cu(2+) interaction and Cu(2+)-driven free radical formation with Aβ40 c...

MOTIVATION The coiled coil is a ubiquitous α-helical protein-structure domain that directs and facilitates protein-protein interactions in a wide variety of biological processes. At the protein-sequence level, the coiled coil is readily recognized via a conspicuous heptad repeat of hydrophobic and polar residues. However, structurally coiled coils are more complicated, existing in a wide range ...

The de novo design of peptides and proteins has recently emerged as an approach for investigating protein structure and function. Designed, helical peptides provide model systems for dissecting and quantifying the multiple interactions that stabilize secondary structure formation. De novo design is also useful for exploring the features that specify the stoichiometry and stability of alpha-heli...

We have investigated the process of the assembly of the Dictyostelium discoideum cortexillin I oligomerization domain (Ir) into a tightly packed, two-stranded, parallel coiled-coil structure using a variety of recombinant polypeptide chain fragments. The structures of these Ir fragments were analyzed by circular dichroism spectroscopy, analytical ultracentrifugation and electron microscopy. Del...

Turbulent heat transfer in Helically Corrugated Tubes (HCT) was numerically investigated for pure water and SiO2 nanofluid using Computational Fluid Dynamics (CFD). This study was carried out for different corrugating pitches (5, 7, 8 mm) and heights (0.5, 0.75, 1.25 mm) at various Reynolds numbers ranging from 5000 to 13300. The effect of nanoparticles on heat transfer augmentation for plain t...