[reaction: see text] The Bergman cyclization of benzannelated enediynes is highly sensitive to ortho substitution. This finding opens possibilities for the rational design of conformer-specific and pH-dependent DNA-cleaving agents.

5-Membered heterocycles are employed to give a conformer independent DDA array of hydrogen bonds, resulting in enhanced binding affinity to a complementary AAD array in comparison to a DDA array employing a 6-membered ring.

The cis – trans -isomerism of the propiolic acid monomer (HCC–COOH) is examined with linear Raman jet spectroscopy, yielding first environment-free vibrational band centres a higher-energy -rotamer beyond formic (HCOOH) in addition to all fundamentals and large number hot combination/overtone bands -conformer.

Eight meso-aryl calixphyrin derivatives were synthesized and their conformational equilibria and transitions studied with temperature-dependent NMR spectroscopy. On the basis of density functional computations, several conformer species could be identified and observed changes in chemical shifts explained. In some compounds, the aryl group rotation and porphyrin ring flipping could be monitored...

A plausible explanation for the unprecedented formation of two conformational isomers of bisphenyldirhodium(III) caprolactamate is presented. The presence of acetic acid during the coupling process leading to the formation of bisphenyldirhodium(III) caprolactamate is shown to increase the propeller conformer at the expense of the biplanar conformer, Acetic acid is also found to catalyze the dec...

The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family. Here we present the structure of the Caenorhabditis elegans TRIP13 ortholog PCH-2, revealing a new family of AAA+ ATPase protein remodelers. PCH-2 possesses a substrate-recognition domain related to those of the protein...