OBJECTIVE The aim of this study was to study the regulatory functions of docosahexaenoic acid (DHA) on resting potential (RP), action potential duration (APD), delayed rectifier potassium current (Ik), and inwardly rectifier potassium current (Ik1) in rat ventricular myocytes, and analyze the related anti-arrhythmia mechanism. MATERIALS AND METHODS Rat ventricular myocytes were isolated by en...

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UNLABELLED Measurement of free radical scavenging capacity of antioxidants is influenced by a number of parameters that depend on reaction rate. AIM A new method for assessing the free radical scavenging activity in which the influence of antioxidant concentration and reaction rate on chlorpromazine radical cation absorbance are simultaneously monitored. MATERIALS AND METHODS The change in ...

An evaluation model of aluminum alloy welded joint low-cycle fatigue data based on information entropy is proposed. Through calculating and analyzing the information entropy of decision attributes, quantitative contribution of stress concentration, plate thickness, and loading mode to the fatigue destruction are researched. Results reveal that the total information entropy of the fatigue data b...

Measurements of gas exchange characteristics were made on intact, attached leaves of hydroponically grown seedlings of Avicennia marina (Forstk.) Vierh. var australasica (Walp.) Moldenke as the NaCl concentration of the culture solution was varied by step changes of 50 millimolar NaCl every 2nd day from 50 to 500 to 50 millimolar NaCl. The CO(2) assimilation rate, stomatal conductance, intercel...

This study was designed to investigate the inhibitory effect of Gynura procumbens extract against carbohydrate digesting enzymes and its ability to ameliorate postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. G. procumbens extract showed prominent α-glucosidase and α-amylase inhibitory effects. The half-maximal inhibitory concentration (IC50) of G. procumbens extract aga...

BACKGROUND A fixed-dose combination of daclatasvir (DCV; hepatitis C virus NS5A inhibitor), asunaprevir (ASV; non-structural protein 3 inhibitor), and beclabuvir (BCV; non-structural protein 5B inhibitor) is approved in Japan for hepatitis C virus genotype 1. OBJECTIVE The objective of this study was to assess the combination's drug-drug interaction potential in vivo using a validated cocktai...

Production of Cas9 mRNA in vitro typically requires the addition of a 5´ cap and 3´ polyadenylation. A plasmid was constructed that harbored the T7 promoter followed by the EMCV IRES and a Cas9 coding region. We hypothesized that the use of the metastasis associated lung adenocarcinoma transcript 1 (Malat1) triplex structure downstream of an IRES/Cas9 expression cassette would make polyadenylat...

This paper develops a general equilibrium model with the purpose of identifying fundamental determinants of market structure and their welfare impact. The main effects are derived from the interaction between horizontal and vertical differentiation, induced by different sets of exogenous and endogenous sunk costs. The former are found to be positively correlated with market concentration and ma...

The aim of this study was to investigate differences in organic anion transporting polypeptide 1A2 activity among the Taiwanese population via an analysis of 3 pharmacokinetic studies completed in a total of 103 healthy male Taiwanese subjects. The pharmacokinetics of fexofenadine was measured as an indicator of organic anion transporting polypeptide 1A2 activity. Using the Kolmogorov-Smirnov t...