Platelet concentrates have been used in various applications within Oral and Maxillofacial Surgery and Implantology with the aim of promote tissue repair. The first generation of platelet concentrates is Platelet-Rich Plasma (PRP) and recent studies question its actual effectiveness on tissue healing because of the rapid release of growth factors. The second generation of platelet concentrates,...

blood transfusion centers are under considerable pressure to produce platelet concentrates with high quality and safety due to the short shelf life of 3-5 days as well as possible bacterial and viral contaminations. for a variety of reasons, many europeans have changed their methods of component production from whole blood using the north american standard platelet-rich plasma method to the buf...

Protein C is one of the major inhibitors of the coagulation system that downregulate thrombin generation. Severe congenital protein C deficiency leads to a hypercoagulability state that usually presents at birth with purpura fulminans and/or severe venous and arterial thrombosis. Recurrent thrombotic events are commonly seen. From the 1990's, several virus-inactivated human protein C concentrat...