Composite interval mapping was used to identify life-span QTL in F2 progeny of three crosses between different pairs of inbred lines. Each inbred line was derived from a different outbred population that had undergone long-term selection for either long or short life span. Microsatellite loci were used as genetic markers, and confidence intervals for QTL location were estimated by bootstrapping...

To quantitatively evaluate drug-drug interactions involving metabolic processes in the liver, we attempted to predict the increasing ratio of the plasma concentration of midazolam (MDZ) in the presence of cimetidine (CIM) or nizatidine (NZD) in rats. Under steady-state conditions for the plasma concentration of CIM or NZD, MDZ was administered through the portal vein. The AUC of MDZ in the pres...

Communication systems continue to offer potential for improving ·the efficiency of manufacturing enterprises through Computer Integrated Manufacturing (CIM). This potential cannot, however, be realized by developments on the communications front alone. We discuss CIM issues on several fronts and endeavor to relate developments on the communications front to what we believe to be some of the maj...

Compute-in-memory (CiM) is a promising approach to alleviating the memory wall problem for domain-specific applications. Compared current-domain CiM solutions, charge-domain shows opportunity higher energy efficiency and resistance device variations. However, area occupation standby leakage power of existing SRAM-based (CD-CiM) are high. This brief proposes first concept analysis CD-CiM using n...

Increasing grain yield by the selection for optimal plant architecture has been the key focus in modern maize breeding. As a result, leaf angle, an important determinant of plant architecture, has been significantly improved to adapt to the ever-increasing plant density in maize production over the past several decades. To extend our understanding on the genetic mechanisms of leaf angle in maiz...

Changes in market and production profiles require a more flexible concept of manufacturing. Computer Integrated Manufacturing (CIM) describes an integrative concept for joining business and manufacturing islands. In this context database technology is the key technology for implementing the CIM philosophy. However, CIM applications are more complex and thus, more demanding than traditional data...

The response time to cimaterol (CIM), a beta-adrenergic agonist, by broiler chickens for carcass characteristics, muscle composition, muscle fiber size, catheptic enzyme activity, and tenderness was determined. Two trials were conducted in which chickens were fed a control diet (CON) containing 0 ppm of CIM or a diet containing 1 ppm of CIM. Trial 1 consisted of 55, 31-d-old broiler chickens in...

A refined cluster-in-molecule (CIM) method for local correlation calculations of large molecules is presented. In the present work, two new strategies are introduced to further improve the CIM approach: (1) Some medium-range electron correlation energies, which are neglected in the previous CIM approach, are taken into account. (2) A much simpler procedure using only a distance threshold is use...