نتایج جستجو برای: complementing group 1 xrcc1 gene

تعداد نتایج: 4202903  

2014
Katiboina Srinivasa Rao Abialbon Paul Annan Sudarsan Arun Kumar Gurusamy Umamaheswaran Biswajit Dubashi Karunanithi Gunaseelan Steven Aibor Dkhar

Various DNA repair pathways protect the structural and chemical integrity of the human genome from environmental and endogenous threats. Polymorphisms of genes encoding the proteins involved in DNA repair have been found to be associated with cancer risk and chemotherapeutic response. In this study, we aim to establish the normative frequencies of DNA repair genes in South Indian healthy popula...

2016
Saghar Pahlavanneshan Amirhossein Ahmadi Mohammadali Boroumand Saeed Sadeghian Mehrdad Behmanesh

OBJECTIVES Coronary artery disease (CAD) is the leading cause of death in both male and female worldwide. The main cause of CAD is the atherosclerosis of coronary arteries, which is, mostly caused by genetic alteration. 50% of such cases occur in mitotic cells where single-strand breaks occur spontaneously or due to ionizing radiation. X-ray repair cross-complementing protein 1 (XRCC1) as a key...

Journal: :Saudi medical journal 2015
Mazhar S Al Zoubi

OBJECTIVES To elucidate the contribution of x-ray repair cross-complementing (XRCC) protein 1 399Gln, XRCC3 241M, and XRCC3-5'-UTR polymorphisms to the susceptibility of breast cancer (BC) in a Jordanian population. METHODS Forty-six formalin fixed paraffin embedded tissue samples from BC diagnosed female patients, and 31 samples from the control group were subjected to DNA sequencing. Sample...

2011
G. Padma M. Mamata K. Ravi Kumar Reddy T. Padma

PURPOSE Age related cataract is the leading cause of blindness in the world today. The association between DNA damage to the lens epithelium and the development of lens opacities has been reported in many studies. Polymorphisms of DNA repair enzymes may affect repair efficiency and thereby lead to the development of age related cataract. METHODS In this study, we aimed to determine the freque...

2010
Pei-Liang Chen Kun-Tu Yeh Yi-Yu Tsai Hank Koeh Yu-Ling Liu Huei Lee Ya-Wen Cheng

PURPOSE Epidemiological evidence suggests that UV irradiation plays an important role in pterygium pathogenesis. UV irradiation can produce a wide range of DNA damage. The base excision repair (BER) pathway is considered the most important pathway involved in the repair of radiation-induced DNA damage. Based on previous studies, single-nucleotide polymorphisms (SNPs) in 8-oxoguanine glycosylase...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2012
Ke Qian Kui-Jie Liu Feng Xu Xian-Yu Chen Gan-Nong Chen Wen-Jun Yi En-Xiang Zhou Zhong-Hua Tang

A number of studies have been conducted to explore the association of XRCC1 polymorphisms with thyroid cancer risk, but the results have been inconsistent. Thus we performed the present meta-analysis to clarify this issue based on all of the evidence available to date. Relevant studies were retrieved by searching PubMed and statistical analysis conducted using Stata software. Nine studies were ...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2012
Yi Zhao Xin Deng Zhen Wang Qiang Wang Yixia Liu

AIM The distribution of DNA repair gene XRCC1 and XRCC3 genotypes was used to assess the potential influence of genetic polymorphisms on risk of colorectal cancer, and interactions with other factors. METHODS A 1:2 matched case-control study was conducted with 485 cases and 970 controls. XRCC1 and XRCC2 genotype polymorphisms were based upon duplex polymerase-chain-reaction with the confronti...

2012
Libing Wang Fan Yin Xia Xu Xiaoxia Hu Dongbao Zhao

BACKGROUND Recently, there have been a number of studies on the association between XRCC1 polymorphisms and childhood acute lymphoblastic leukemia (ALL) risk. However, the results of previous reports are inconsistent. Thus, we performed a meta-analysis to clarify the effects of XRCC1 variants on childhood ALL risk. METHODS A meta-analysis was performed to examine the association between XRCC1...

Journal: :Genetics and molecular research : GMR 2013
Z Y Zhang Y Xuan X Y Jin X Tian R Wu

We made a meta-analysis of the association between X-ray cross-complementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and esophageal cancer (EC) risk. Statistical analysis was performed with the Review Manager version 4.2.8 software program and STATA version 11.0. We selected 16 case-control studies for this meta-analysis, including 3591 EC cases and 5752 controls. Overall, the Gln399 alle...

Journal: :The Journal of pharmacology and experimental therapeutics 2007
Jane L Rose Kevin C Reeves Rostislav I Likhotvorik Dale G Hoyt

Engagement of integrin cell adhesion receptors suppresses bleomycin (BLM)-induced DNA strand breakage in endothelial cells. Previous investigation of cells from poly(ADP-ribose) polymerase (PARP)-1 knockout mice and with an inhibitor of the enzyme indicated that this facilitator of base excision repair (BER) is required for integrin-mediated suppression of DNA strand breakage. Here, small inhib...

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