Complement is important to host defense and the regulation of inflammation. The liver is overwhelmingly the major source of circulating complement. However, many other organs are capable of synthesizing some or all of the complement components in a regulated tissue-specific manner. There is increasing evidence that this locally generated complement is biologically active and exerts powerful eff...

abstract: new approaches to strategy have accepted strategic thinking as a complement or even an alternative for strategic planning. indeed, strategic thinking capability has been recognized as a characteristic of successful top managers in organizations. moreover, the extant literature emphasizes the fact that top level managers can be taught to think strategically. however, there is no compre...

The complement system, a well-characterised arm of the innate immune system, significantly influences the adaptive immune response via direct cell-cell interaction and maintenance of lymphoid organ architecture. Development of vaccines is a major advance in modern health care. In this review, we highlight the importance of the marginal zone in response to both, polysaccharide and conjugated vac...

Thrombin-mediated platelet membrane-specific uptake of C3 and C5 was demonstrated by radiolabeled components and was visualized electron microscopically utilizing a ferritin marker conjugated to monospecific antibody to each component. The role of complement in thrombin-induced platelet function was determined. Though complement was not essential for thrombin-induced platelet aggregation and re...

Opt imum killing of gram-negative bacteria in serum requires the participation of terminal components of the complement system, presumably through formation of a membrane attack complex (MAC) 1 containing complement components C5b6789 (13). Although it is clear that some gram-negative bacteria are highly resistant to serum killing in the presence of adequate antibody, the mechanism of this resi...