نتایج جستجو برای: comet assay

تعداد نتایج: 225520  

2005
PETER C. THOMAS JOSEPH VEVERKA MICHAEL F. A’HEARN LUCY MCFADDEN MICHAEL J. S. BELTON JESSICA M. SUNSHINE

The Deep Impact mission will provide the highest resolution images yet of a comet nucleus. Our knowledge of the makeup and structure of cometary nuclei, and the processes shaping their surfaces, is extremely limited, thus use of the Deep Impact data to show the geological context of the cratering experiment is crucial. This article briefly discusses some of the geological issues of

Journal: :Current Biology 2001
Lisa A. Cameron Tatyana M. Svitkina Danijela Vignjevic Julie A. Theriot Gary G. Borisy

Polymerization of actin filaments is necessary for both protrusion of the leading edge of crawling cells and propulsion of certain intracellular pathogens, and it is sufficient for generating force for bacterial motility in vitro. Motile intracellular pathogens are associated with actin-rich comet tails containing many of the same molecular components present in lamellipodia, and this suggests ...

2007
Alina Błaszczyk Janusz Skolimowski

Ethoxyquin phosphate (EQ-P) and ethoxyquin hydrochloride (EQ-HCl) were synthesized and studied for genotoxic and antioxidant activities with the use of comet assay and micronucleus test performed on human lymphocytes. The results were compared with the activities of the earlier studied ethoxyquin (EQ; 1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline), a strong antioxidant used mainly as a preserva...

Journal: :Toxicology Letters 2021

• Pre-validation study on comet assay for detecting site of contact genotoxicity. Acrylic implants containing EMS (AF + EMS) was used as test item. AF showed DNA damage at using whereas negative Ames and chromosome aberration test. Implants may cause ‘site genotoxicity’ without systemic Comet has potential use in medical device biocompatibility assessment. Toxicological risk assessment devices ...

Journal: :Science 2001
T L Farnham D G Schleicher L M Woodney P V Birch C A Eberhardy L Levy

We analyzed photometric measurements and images of comet C/LINEAR before perihelion and after its breakup. Results from our photometry data include a lower limit of 0.44 kilometer for the radius of the nucleus before breakup, and a determination that it was depleted in carbon-chain molecules relative to most other comets. Our imaging and modeling results, which include a constraint on the rotat...

Journal: :Science 2011
Michael F A'Hearn Michael J S Belton W Alan Delamere Lori M Feaga Donald Hampton Jochen Kissel Kenneth P Klaasen Lucy A McFadden Karen J Meech H Jay Melosh Peter H Schultz Jessica M Sunshine Peter C Thomas Joseph Veverka Dennis D Wellnitz Donald K Yeomans Sebastien Besse Dennis Bodewits Timothy J Bowling Brian T Carcich Steven M Collins Tony L Farnham Olivier Groussin Brendan Hermalyn Michael S Kelley Jian-Yang Li Don J Lindler Carey M Lisse Stephanie A McLaughlin Frédéric Merlin Silvia Protopapa James E Richardson Jade L Williams

Understanding how comets work--what drives their activity--is crucial to the use of comets in studying the early solar system. EPOXI (Extrasolar Planet Observation and Deep Impact Extended Investigation) flew past comet 103P/Hartley 2, one with an unusually small but very active nucleus, taking both images and spectra. Unlike large, relatively inactive nuclei, this nucleus is outgassing primari...

Journal: :Science 2017
M Ramy El-Maarry O Groussin N Thomas M Pajola A-T Auger B Davidsson X Hu S F Hviid J Knollenberg C Güttler C Tubiana S Fornasier C Feller P Hasselmann J-B Vincent H Sierks C Barbieri P Lamy R Rodrigo D Koschny H U Keller H Rickman M F A'Hearn M A Barucci J-L Bertaux I Bertini S Besse D Bodewits G Cremonese V Da Deppo S Debei M De Cecco J Deller J D P Deshapriya M Fulle P J Gutierrez M Hofmann W-H Ip L Jorda G Kovacs J-R Kramm E Kührt M Küppers L M Lara M Lazzarin Z-Yi Lin J J Lopez Moreno S Marchi F Marzari S Mottola G Naletto N Oklay A Pommerol F Preusker F Scholten X Shi

The Rosetta spacecraft spent ~2 years orbiting comet 67P/Churyumov-Gerasimenko, most of it at distances that allowed surface characterization and monitoring at submeter scales. From December 2014 to June 2016, numerous localized changes were observed, which we attribute to cometary-specific weathering, erosion, and transient events driven by exposure to sunlight and other processes. While the l...

2017
Paula R. Williamson Douglas G. Altman Heather Bagley Karen L. Barnes Jane M. Blazeby Sara T. Brookes Mike Clarke Elizabeth Gargon Sarah Gorst Nicola Harman Jamie J. Kirkham Angus McNair Cecilia A. C. Prinsen Jochen Schmitt Caroline B. Terwee Bridget Young

The selection of appropriate outcomes is crucial when designing clinical trials in order to compare the effects of different interventions directly. For the findings to influence policy and practice, the outcomes need to be relevant and important to key stakeholders including patients and the public, health care professionals and others making decisions about health care. It is now widely ackno...

Journal: :iranian journal of radiation research 0
k. rajesha nairy depatment of studies in physics, mangalore university, mangalagangotri-574 199, india n.n. bhat radiological protection and advisory division, bhabha atomic research center, mumbai-400 085, india p. joseph depatment of studies in physics, mangalore university, mangalagangotri-574 199, india g. sanjeev depatment of studies in physics, mangalore university, mangalagangotri-574 199, india n. yerol depatment of studies in physics, mangalore university, mangalagangotri-574 199, india

background: exposure to ionizing radiation is known to induce oxidative stress followed by damage to critical biomolecules like lipids, proteins and dna through radiolysis of cellular water. since radiation has been widely used as an important tool in therapy of cancer, the detailed investigation regarding the dna damage and repair kinetics would help to predict the radiation sensitivity of cel...

Journal: :Mutagenesis 2012
Marcin Kruszewski Teresa Iwaneńko Eugeniusz K Machaj Tomasz Ołdak Maria Wojewódzka Lucyna Kapka-Skrzypczak Zygmunt Pojda

The comet assay or single cell gel electrophoresis has proven to be a versatile and sensitive method of measuring the induction and repair of DNA damage in individual cells. However, one of the drawbacks of the assay is the bias caused by changes in the ability of cells to repair DNA damage in different cell cycle phases. Whereas the bias seems less important when G0 peripheral blood lymphocyte...

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