Curcumin has been traditionally used in food recipes for biological health benefits. However, these properties are compromised due to its very low bioavailability. Thus, this work assessed the impact of using natural potential bioenhancers improve intestinal permeability and understanding interaction flavonoids with curcuminoids through molecular dynamic simulation. The (Papp) was measured on h...

RON is a receptor tyrosine kinase belonging to the MET proto-oncogene family. The purposes of this study are to determine the expression and activation of RON in a panel of human colon carcinoma cell lines. Western blotting showed that RON is barely detectable in normal and SV-40-transformed colon epithelial cells, but highly expressed and constitutively activated in several colon carcinoma cel...

background and objective: garlic has been known worldwide as a dietary constituent with many pharmacological effects. the present in vitro study was designed to investigate the putative anticancer effect of garlic extract on cancer cells, and if this effect was through apoptosis induction. material and methods:  human colon adenocarcinoma cells ht29 were treated with different doses (1, 5 and 1...

background & objectives:  cd10 is a cell surface enzyme with metalloendopeptidase activity, also known as common acute lymphoblastic leukaemia antigen, which mainly serves as a marker for acute lymphoblastic leukemia (all). to date and to the best of our knowledge, only few comparative immunohistochemical studies have assessed cd10 expression in cutaneous epithelial neoplasms. our goal was ...

background: prostate cancer is one of the leading causes of cancer deaths among men. new gene expressed in prostate (ngep), is a prostate-specific gene expressed only in normal prostate and prostate cancer tissue. because of its selective expression in prostate cancer cell surface, ngep is a potential immunotherapeutic target. to target the ngep in prostate cancer, it is essential to investigat...

We have previously shown that a human colon carcinoma cell line (SW1222) expresses a collagen receptor recognizing the Arg-Gly-Asp tripeptide sequence found in collagen. This receptor mediates the cellular attachment to collagen and, subsequently, the glandular differentiation seen in a three-dimensional collagen gel culture. In a search to identify cell surface molecules mediating the adhesion...

the marine environment represents approximately half of the global biodiversity and could provide unlimited biological resources for the production of therapeutic drugs. marine seaweeds comprise few thousands of species representing a considerable part of the littoral biomass. extracts of the cystoseira indica and cystoseira merica were subjected to phytochemical and cytotoxicity evaluation. th...

Colon carcinoma cells overexpress c-myc due to defective Wnt signaling, but only patients whose tumors have an amplified c-myc gene show improved disease-free and overall survival in response to 5-fluoruracil (5FU). Here we show that in two colon carcinoma cell lines that do not have an amplified c-myc gene but differ in their p53 status, high c-myc levels can be further elevated by introducing...