tendons are frequently targets of injury in sports and work. whether nonsteroidal anti-inflammatory drugs (nsaids) have beneficial effects on tendon healing is still a matter of debate. this study was conducted to evaluate effects of flunixin meglumine (fm) on tendon healing after experimentally induced acute trauma. twenty eight adult male new zealand white rabbits were subjected to complete t...

nicotine is one the chemical substance with high level of toxically. it crosses the placenta and accumulates in the developing organs of fetus. our previous investigations indicated that collagen type iv plays a key role in basement membrane of various embryonic organs. in this study we evaluated the effect of maternal nicotine exposure pre and postnatal period on collagen iv expression during ...

objective(s):skin extracellular matrix, which contains type i and type iii collagens, is involved in skin development. the aim of this study was to investigate type iii collagen distribution pattern as well as its changes during pre and post-natal skin morphogenesis in rats. materials and methods: ventral skins of wistar rat embryos at different stages from 10 to 20 gestational day (e10-e20) an...

Little is known about collagen metabolism in heart failure, with or without left ventricular systolic dysfunction. We studied serum concentrations of the carboxy-terminal propeptide of procollagen type I (PIP), a marker of collagen type-I synthesis, and of the carboxy-terminal telopeptide of collagen type I (ICTP), a marker of collagen type-I degradation, in 70 patients admitted for heart failu...

Osteogenesis imperfecta is a hereditary connective tissue disorder characterized primarily by fractures with no or small causal antecedent; in most patients this is a consequence of diminished or abnormal production of collagen type I. It is a clinically heterogeneous disorder: it has been proposed recently to classify osteogenesis imperfecta in types I-V on the basis of the clinical picture an...

Autoimmune hepatitis is characterized by inflammation in liver histology, circulating autoantibodies, and increased levels of immunglobulin G, the absence a known etiology. There are different clinical types described children. Because presentation autoimmune with findings, establishment diagnosis may be difficult. In last two decades, 6-fold increase incidence has been reported thanks to updat...

Objective(s): Epidermolysis bullosa is one of the most important series of mechano-bullous heritable skin disorders which is categorized into four major types according to the layer that bullae forms within basement membrane zone. In dystrophic form of the disease, blisters are made in the sublamina densa zone, at the level of type VII collagen protein which produce anchoring fibrils. Type VII ...

Recessive dystrophic epidermolysis bullosa (RDEB) is a rare skin disorder characterized by defects in collagen VII leading to range of pathologies dominated painful blister formation. Aberrant wound healing leads fibrosis that contributes life threatening cancers. We have developed an vitro model fibrotic extracellular matrix (ECM) produced primary RDEB patient dermal fibroblasts, which we use ...

Osteogenesis imperfecta is a disorder of the formation collagen tissue that functions as connective and caused by gene mutation causes disturbances in type 1 collagen. This study aimed to describe diagnosis osteogenesis imperfecta. A 23-year-old man came rheumatology polyclinic Dr. Mohammad Hoesin General Hospital Palembang with complaint recurrent fractures since ± 17 years ago. The patient al...