The effects of thermal acclimation were investigated in the common carp Cyprinus carpio L. Acclimation and acute temperature effects were tested during ontogeny from larval [9.5 mm total length (L)] to juvenile (69.0 mm L) stages and between 8 and 21 degrees C. The myosin heavy chain (MHC) composition, myofibrillar Mg(2+)-Ca(2+)-ATPase activity, and muscle strains showed significant thermal acc...

Recently, with the rapid development of big data, Internet of Things (IoT) brings more and more intelligent and convenient services to people’s daily lives. Mobile healthcare crowd sensing (MHCS), as a typical application of IoT, is becoming an effective approach to provide various medical and healthcare services to individual or organizations. However, MHCS still have to face to different secu...

Background Statistical models that use an individual's DNA methylation levels to estimate their age (known as epigenetic clocks) have recently been developed, with 96% correlation found between epigenetic and chronological age. We postulate that differences between estimated and actual age [age acceleration (AA)] can be used as a measure of developmental age in early life. Methods We obtained...

Background. The Journal Citation Reports journal impact factors (JIFs) are widely used to rank and evaluate journals, standing as a proxy for the relative importance of a journal within its field. However, numerous criticisms have been made of use of a JIF to evaluate importance. This problem is exacerbated when the use of JIFs is extended to evaluate not only the journals, but the papers there...

BACKGROUND: Evidence regarding nighttime physician staffi ng of ICUs is suboptimal. We aimed to determine how nighttime physician staffi ng models infl uence patient outcomes. METHODS: We performed a multicenter retrospective cohort study in a multicenter registry of US ICUs. Th e exposure variable was the ICU’s nighttime physician staffi ng model. Th e primary outcome was hospital mortality. S...

Beginning in 2001, the Millennium Cohort began enrollment of a stratified random sample of more than 140,000 service members, with the intention of following their health for up to 20 years. Cohort members will provide self-reported data on medical symptoms, functional status, and health-related behavior every 3 years. New and existing sources of objective data on health and health-related expo...

Background: The cause-of-death register at the Southern Urals Biophysics Institute (SUBI), Ozyorsk, Russia, was established to document the number and causes of deaths in the Mayak workers cohort, which includes all persons (N = 22,377) employed at Mayak nuclear facility between 1948 and 1982. Most workers were occupationally exposed to high doses of ionizing radiation and have been shown to ha...