PURPOSE We determined if the Bruch's membrane opening (BMO) location changes over time in healthy eyes and eyes with progressing glaucoma, and validated an automated segmentation algorithm for identifying the BMO in Cirrus high-definition coherence tomography (HD-OCT) images. METHODS We followed 95 eyes (35 progressing glaucoma and 60 healthy) for an average of 3.7 ± 1.1 years. A stable group...

BACKGROUND Wearable devices are gaining increasing market attention; however, the monitoring accuracy and consistency of the devices remains unknown. OBJECTIVE The purpose of this study was to assess the consistency of the monitoring measurements of the latest wearable devices in the state of normal activities to provide advice to the industry and support to consumers in making purchasing cho...

Force platforms are used extensively to measure force and power output during countermovement jump (CMJ). The purpose of this study was to examine measurement reliability and validity of commonly used performance measurements derived from ground reaction force (GRF)-time data during CMJ and the influence of sampling at different frequencies. Twenty-four men performed 2 trials of CMJ on a force ...

Background Different ultrasound parameters have been frequently used to assess changes associated with training, aging, immobilization, and neuromuscular diseases. However, an exploratory reliability analysis of the echo intensity (EI) and muscle thickness (MT) of the forearm flexors is scarce, especially in women. Objective The purpose of the present study was to determine the intra-rater re...

BACKGROUND & OBJECTIVES Mass administration of ivermectin drug was carried out annually between 1995 and 2001 in three villages that were endemic for onchocerciasis in the Lower Cross River Basin, Nigeria. The aim of this study was to evaluate the population dynamics (dispersion patterns, distribution, prevalence and intensity) of Onchocerca volvulus microfilariae in their human host after six ...

Mo*ller and Thornhill (1997) assessed the heritability of developmental stability by a meta-analysis of all published (and some unpublished) heritability estimates of fluctuating asymmetry in bilateral traits. From a limited number of these studies they also calculated the additive genetic coefficient of variation (CVA). The usefulness of CVA is that it may correct for covariance between phenot...

The measurement of airway resistance by the interrupter technique (Rint) needs standardization. Should measurements be made be during the expiratory or inspiratory phase of tidal breathing? In reported studies, the measurement of Rint has been calculated as the median or mean of a small number of values, is there an important difference? Subjects were 2.5-5.0 yrs (median 4.0 yrs) who had previo...

By using lactose colored with erythrocin, we examined the effect of particle size on mixing degree during the preparation of triturations with a mortar and pestle. We used powders with different distributions of particle sizes, i.e., powder that passed through 32-mesh but was trapped on a 42-mesh sieve (32/42-mesh powder), powder that passed through a 42-mesh sieve but was trapped on a 60-mesh ...

Content uniformity (CU) of tablets is a critical property that needs to be well controlled in pharmaceutical products. Methods that predict the CU accurately can greatly help in reducing the development efforts. This article presents a statistical mechanical framework for predicting CU based on first principles at the molecular level. The tablet is modeled as an open system that can be treated ...

A common application of multilevel models is to apportion the variance in the response according to the different levels of the data.Whereas partitioning variances is straightforward in models with a continuous response variable with a normal error distribution at each level, the extension of this partitioning to models with binary responses or to proportions or counts is less obvious. We descr...