To investigate regulation of human immunoglobulin heavy chain expression, we have cloned DNA downstream from the two human Calpha genes, corresponding to the position in the mouse IgH cluster of a locus control region (LCR) that includes an enhancer which regulates isotype switching. Within 25 kb downstream of both the human immunoglobulin Calpha1 and Calpha2 genes we identified several segment...

A fractional diffusion equation based on Riemann-Liouville fractional derivatives is solved exactly. The initial values are given as fractional integrals. The solution is obtained in terms of H-functions. It differs from the known solution of fractional diffusion equations based on fractional integrals. The solution of fractional diffusion based on a Riemann-Liouville fractional time derivative...

In the title compound, C(12)H(13)N(3)O(2), the dihedral angle between the oxazolone ring and the benzimidazole unit is 45.0 (5)°, exhibiting a staggered conformation at the Cα-Cβ bond. In the crystal, a strong N-H⋯N hydrogen bond links the mol-ecules into a C(4) chain along the c axis while a C-H⋯O hydrogen-bonding inter-action generates a C(5) chain along the a axis, i.e. perpendicular to the ...

On bounded domains Ω ⊂ R2 we consider the anisotropic problems u−auxx + u−buyy = p(x, y) in Ω with a, b > 1 and u = ∞ on ∂Ω and uuxx+uuyy+q(x, y) = 0 in Ω with c, d ≥ 0 and u = 0 on ∂Ω. Moreover, we generalize these boundary value problems to space-dimensions n > 2. Under geometric conditions on Ω and monotonicity assumption on 0 < p, q ∈ Cα(Ω) we prove existence and uniqueness of positive solu...

The overview of Autolink. The overview of Autolink is shown in Figure 1. The input data are spin systems obtained from CARA [2]. All possible spin system parings are considered and a “fitness” score is computed for each pair. A pair of spin systems and their fitness score form a “link hypothesis”. Each fitness score consists of several sub-scores representing specific resonance comparisons, suc...

Orthologous genes involved in the formation of proteins associated with memory acquisition are similarly expressed in forebrain centres that exhibit similar cognitive properties. These proteins include cAMP-dependent protein kinase A catalytic subunit (PKA-Cα) and phosphorylated Ca(2+)/calmodulin-dependent protein kinase II (pCaMKII), both required for long-term memory formation which is enrich...

The effects and mechanism of pulp delignification by laccases in the presence of redox mediators have been investigated on unbleached eucalyptus kraft pulp treated with laccases from Pycnoporus cinnabarinus (PcL) and Myceliophthora thermophila (MtL) and 1-hydroxybenzotriazole (HBT) and methyl syringate (MeS) as mediators, respectively. Determination of the corrected κ number in eucalyptus pulps...

Platelet-activating factor (PAF) acting via its receptor (PAFR) is implicated in the pathogenesis of persistent pulmonary hypertension of the newborn (PPHN). Effects of long-term oxygen therapy on newborn lung are not well understood; therefore, we studied the effect of oxygen tension on ovine newborn pulmonary artery smooth muscle cells (NBPASMC). Our global hypothesis is that PPHN results fro...