In spite of its many other benefits, DNA vaccine is limited in its application by its insufficient immunogenicity. One promising approach for enhancing its immunogenicity is to maximize its expression in the immunized host. In the current study, we investigated whether codon optimization of the mycobacterial antigen Ag85B gene could enhance the expression and immunogenicity of the Ag85B DNA vac...

Salidroside, a plant secondary metabolite in Rhodiola, has been demonstrated to have several adaptogenic properties as a medicinal herb. Due to the limitation of plant source, microbial production of salidroside by expression of plant uridine diphosphate glycosyltransferase (UGT) is promising. However, glycoside production usually remains hampered by poor expression of plant UGTs in microorgani...

This paper presents a new method for multiple person multiple attribute decision making (MADM) based on decision makers' subjective preference information on alternatives and objective decision matrix. In this method, multiple decision makers give their preference information on the alternatives in different formats, and an optimization model is constructed to reflect both decision makers' subj...

We introduce a new variant of hedonic coalition formation games in which agents have two levels of preference on their own coalitions: preference on the set of “roles” that makes up the coalition, and preference on their own role within the coalition. We define several stability notions and optimization problems for this model. We prove the hardness of the decision problems related to our optim...

BACKGROUND Microbial polyhydroxyalkanoates (PHA) are biopolyesters consisting of diverse monomers. PHA synthase PhaC2Ps cloned from Pseudomonas stutzeri 1317 is able to polymerize short-chain-length (scl) 3-hydroxybutyrate (3HB) monomers and medium-chain-length (mcl) 3-hydroxyalkanoates (3HA) with carbon chain lengths ranging from C6 to C12. However, the scl and mcl PHA production in Escherichi...

Nowadays, the efficient integration of preference querying into standard database technology is an important issue. In some instances, preference queries challenge traditional query processing and optimization. In this paper we study preference database queries involving hard constraints over multiple attributes belonging to several relations. The main bottleneck for such queries is the computa...