Study treatment discontinuation due to adverse event occurred 4% ATV/co and 3% ATV/r subjects through 48-weeks. Treatment-related adverse events occurred in 36% ATV/co and 48% ATV/r subjects; hyperbilirubinemia occurred in 96% and 100%, and ocular icterus or jaundice occurred in 14% and 17%, respectively. Mean estimated glomerular filtration rate (Cockcroft-Gault, mL/min) decreased occurred in ...

Indexation of glomerular filtration rate (GFR) by body surface area (BSA) is often done without raising any questions. In this article, we will shortly review the limitations of such indexation and illustrate potential errors in clinical practice due to this indexation. Adjusting the GFR by BSA is particularly misleading in patients with abnormal body size (obese and anorectic). We will also in...

The semi-direct product of arbitrary two monoids and a presentation for this product have received considerable attention, see for instance [12], [14] and [15]. In [15], Wang defined a trivialiser set of the Squier complex associated with this presentation. In this paper, as a main result, we discuss necessary and sufficient conditions for the standard presentation of the semi-direct product of...

Mastitis is the most common reason for antimicrobial treatment of dairy cows (Grave et al. 1999; Mitchell et al. 1998). Antimicrobials have been used to treat mastitis for more than fifty years, but consensus about the most efficient, safe, and economical treatment is still lacking. The concept of evidence based medicine has recently been introduced to veterinary medicine (Cockcroft & Holmes, 2...

Failure in sheet metal structures of ductile material is usually caused by one of, or a combination of, ductile fracture, shear fracture or localised instability. In this paper the failure of the high strength steel Docol 600DP and the ultra high strength steel Docol 1200M is explored. The constitutive model used in this study includes plastic anisotropy and mixed isotropic-kinematic hardening....

INTRODUCTION Serum cystatin C is more sensitive for glomerular filtration rate (GFR) measurement, but it is not available for clinical use in all laboratories. Regarding the importance of accurate estimation of GFR in kidney transplant recipients, we compared cystatin C-based equations with creatinine-based formulas to estimate GFR as precisely and simply as possible in kidney transplant recipi...

BACKGROUND For the estimation of renal function on the basis of serum creatinine, either the Cockcroft-Gault (CG) equation or the MDRD formula is commonly used. Compared to MDRD (using power functions), CG has the advantage of easy calculability at the bedside. MDRD, however, approaches glomerular filtration rate (GFR) more precisely than CG and gives values corrected for a body surface area (B...

BACKGROUND We aimed to evaluate the performance of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-cystatin C equation in a cohort of elderly Chinese participants. MATERIALS AND METHODS Glomerular filtration rate (GFR) was measured in 431 elderly Chinese participants by the technetium-99m diethylene-triamine-penta-acetic acid ((99m)Tc-DTPA) renal dynamic imaging met...