Background & Aims: Since at early pregnancy (<20 week) fetal thyroid gland is undeveloped, normal development of the Fetal brain is highly dependent on maternal thyroid hormones. There are excessive adverse perinatal outcomes associated with overt and subclinical hypothyroidism such as increase of Abortion, preeclampsia, placenta Abruption, LBW, preterm labor, impaired fetal neuropsychological ...

AIMS Chronic heart failure (HF) is associated with activation of blood coagulation but there is a lack of prospective studies on the association between coagulation markers and incident HF in general populations. We have examined the association between the coagulation markers fibrinogen, von Willebrand Factor (VWF), Factors VII, VIII and IX, D-dimer, activated protein C (APC) and activated par...

Introduction: Effects of exercise on different body systems, especially cardiovascular and musculoskeletal systems are evidenced. There is a dynamic homeostatic balance between coagulation and fibrinolysis in normal circulation. Effect of exercise and training on this homeostatic balance has been studied extensively but there are a few studies with regards to analysis of the effects of train...

(UGIB) is the most common gastrointestinal emergency; the annual incidence of hospital admission for UGIB is 0.1%. The most common cause is peptic ulcer bleeding (PUB), which is noted in 31% to 67% of all cases. 1 Mortality rates have remained unchanged at 6% to 8% because of patient characteristics such as older age, higher incidence of concurrent illness, and high hospitalized chance. 2 Endos...

Introduction: Andropause is a common clinical entity of advanced age, with a decline in androgen levels in males. Many of the signs of male aging are results of this condition with significant decline in their quality of life and adverse effects on multiple organ systems function. Androgen Deficiency of the Aging Male (ADAM) questionnaire is one of the most applied screening tools for androgen ...

symptoms: cephalhematomas, injury-related bleeding and bleeding into the skin, manifesting as petechiae, purpura and ecchymoses. Persistent oozing from the umbilical stump is typical for infants with defective fi brinogen production or function and FXIII defi ciency. Joint hemarthroses, typical for severe hemophilias, rarely occur before ambulation. A small proportion of infants with severe coa...

Introduction Thrombocytopenia is a common laboratory finding among critically ill patients. Studies have shown that thrombocytopenia is associated with increased morbidity and mortality, however there is limited evidence showing increasing mortality with increasing severity of thrombocytopenia. Several risk factors, such as sepsis and surgery, have been associated with thrombocytopenia. The rel...