The process of blood coagulation in mammals is complicated, and involves the interaction of more than a dozen coagulation factors as well as a number of proteins from the kininkallikrein system and protein inhibitors. Attempts to model coagulation mathematically have previously focused on a smaller subset of interactions, perhaps one of the pathways or just a portion of one of them (cf. [1],[2]...

There is concern that cyclooxygenase (COX)-2 inhibitors may promote atherothrombosis by inhibiting vascular formation of prostacyclin (PGI2) and an increased thrombotic risk of COX-2 inhibitors has been reported. It is widely accepted that the prothrombotic effects of COX-2 inhibitors can be explained by the removal of platelet-inhibitory PGI2. Using microarray chip technology, we have previous...

Prothrombinase-induced clotting time (PiCT) determines the anticoagulant effects of heparins, low molecular weight heparins (LMWHs), and direct thrombin inhibitors. At present, this is the only method that measures the effects of all of these inhibitors, in contrast to the prothrombin time, activated partial thromboplastin time (aPTT), Heptest, ecarin clotting time, and the chromogenic assays. ...

The major improvements obtained in the quality of commercial reagents and in the accuracy of coagulometers has rendered comparabilty of the results among different laboratories a major task of the bodies devoted to standardization of coagulation testing. Commutability of results is of major importance especially in the monitoring of anticoagulant therapy. Critical aspects relate to the preanaly...

background: gp41 of hiv (human immunodeficiency virus) is a protein that mediates fusion between viral and cellular membranes. the agent, t-20, which has been approved for hiv inhibition, can restrain gp41 function in the fusion process; nevertheless, it has disadvantages like instability, high cost of production and injection form to be delivered twice a day. methods: several molecules like nb...

Anticoagulation is the cornerstone of therapy in patients with ischemic cardiovascular disease. In patients who develop an acute coronary syndrome, following percutaneous coronary interventions, or with an acute ischemic stroke, the rupture or injury of an atherosclerotic arterial plaque serves as a nidus for platelet aggregation and thrombus formation, which, in turn, may cause myocardial infa...

conclusions an hb-driven algorithm, in combination with the “coagulation box” and the early use of clotting factors, could be a simple and effective tool for improving coagulopathy in multiple trauma patients. results over a 12-month investigation period, 123 severe multiple trauma patients needing intensive care therapy were admitted to our trauma center (mean age 48 years, mean iss (injury se...