نتایج جستجو برای: cns diseases
تعداد نتایج: 935417 فیلتر نتایج به سال:
Neurodegenerative disorders encompass a range of conditions affecting the central nervous system (CNS) in which alterations neuronal structure and cellular dysfunction lead to progressive deterioration. Activation microglia expression inflammatory cytokine interleukin-1 (IL-1) CNS have become almost synonymous with neuroinflammation. Additionally, relentless activation IL-1 signalling pathway h...
Permission to reprint a book review printed in this section may be obtained only from the reviewer. The notion that the brain is an " im-munoprivileged site " has been a major impediment to understanding the true importance of the immune system in the pathogenesis of CNS infections. In medical school, we learned about the blood-brain barrier, which limits the entry of inflammatory cells and mol...
Involvement of both 'allergic' and 'autoimmune' mechanisms in EAE, MS and other autoimmune diseases.
Allergic and autoimmune diseases have been considered to be at the opposite sides of the spectrum of the immune response. Autoimmune diseases, such as multiple sclerosis (MS), rheumatoid arthritis and type 1 insulin-dependent diabetes mellitus, are considered T helper 1 (Th1)-mediated diseases, and allergic disorders, such as asthma, food allergy or rhinitis, are considered to be Th2-mediated. ...
Microglia is a type of glial cell located throughout the central nervous system (CNS), which is sensitive to CNS injury and disease. Responsibility of microglia as the resident macrophage cells for injuries suggests that these cells have the potential to act as diagnostic markers of disease beginning or progression. Function of Microglia is strongly synchronized by the microenvironment of brain...
CNS are widespread in nature and formerly regarded as harmless inhabitants of the skin and mucosal linings are now recognized as major cause of significant clinical infections. Correct identification of CNS species has become important in clinical laboratories, since several species have been recognized as potential pathogens, especially in a nosocomial setting (Layer et al., 2006). CNS are als...
The blood-brain barrier (BBB) presents a major obstacle to the treatment of malignant brain tumors and other central nervous system (CNS) diseases. For this reason, a meeting partially funded by an NIH R13 grant was convened to discuss recent advances and future directions in translational research in neuro-oncology and the BBB. Cell biology and transport across the BBB, delivery of agents to t...
Worldwide, more than one billion people are affected by CNS disorders. Despite the huge demand for treatments, existing drugs have limited or no efficacy for some neurological diseases, including brain cancer and certain epilepsies. Furthermore, no effective therapies are available at all for some common disorders of the central nervous system (CNS) such as Alzheimer's disease. ATP-binding cass...
A hallmark of all forms of neurodegenerative diseases is impairment of neuronal functions, and in many cases neuronal cell death. Although the etiology of neurodegenerative diseases may be distinct, different diseases display a similar pathogenesis, for example abnormal immunity within the central nervous system (CNS), activation of macrophage/microglia and the involvement of proinflammatory cy...
neurocysticercosis, is the infection caused by the larval form of the tapeworm taenia solium. it is considered as the most common parasitic disease of the central nervous system and the most common cause of acquired epilepsy. this has primarily been a disease that remains endemic in countries with poor economy , but because of increased migration neurocysticercosis is being diagnosed more frequ...
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