Calcineurin (Cn) is a calcium activated protein phosphatase involved in many aspects of normal T cell physiology, however the role of Cn and/or its downstream targets in leukemogenesis are still ill-defined. In order to identify putative downstream targets/effectors involved in the pro-oncogenic activity of Cn in T-cell acute lymphoblastic leukemia (T-ALL) we used tandem affinity chromatography...

In developing nations, low soil nitrogen (N) availability is a primary limitation to crop production and food security, while in rich nations, intensive N fertilization is a primary economic, energy, and environmental cost to crop production. It has been proposed that genetic variation for root architectural and anatomical traits enhancing the exploitation of deep soil strata could be deployed ...

In the present study non-5-HT1A/non-5-HT1Q binding sites in the rabbit caudate nucleus (CN) were examined to determine if they might be identical to the recently discoverd 5-HT1D sites in the bovine CN. The characterizations were carried out measuring high-affinity [3H]5-HT binding under conditions where 5-HTja and 5-HTjq sites were pharmacologically masked in both tissues. Comparison of the ph...

The self-recombination of the methylene amidogen radical (H(2)CN) is known to be fast and should play an important role in determining the concentration of H(2)CN radicals in both combustion and astrophysical processes. The rate constants of H(2)CN + H(2)CN have been determined by previous experiments, whereas its detailed evolution process and product distribution are still unclear. In this wo...

The CN/CN and CN/CN isotopic ratios have been determined in comets C/1995 O1 (Hale-Bopp), C/2001 Q4 (NEAT) and C/2003 K4 (LINEAR) at heliocentric distances of, respectively, 2.7, 3.7 and 2.6 AU. These ratios have also been measured at r ∼ 1 AU. No significant differences were found between all determinations, nor with the value obtained for other comets. If confirmed, the discrepancy between th...

Noninvasive near infrared spectroscopy measurements were performed to monitor cyanide (CN) poisoning and recovery in the brain region and in foreleg muscle simultaneously, and the effects of a novel CN antidote, sulfanegen sodium, on tissue hemoglobin oxygenation changes were compared using a sub-lethal rabbit model. The results demonstrated that the brain region is more susceptible to CN poiso...

Identifying and locating-dominating codes have been studied widely in circulant graphs of type Cn(1, 2, 3, . . . , r) over the recent years. In 2013, Ghebleh and Niepel studied locatingdominating and identifying codes in the circulant graphs Cn(1, d) for d = 3 and proposed as an open question the case of d > 3. In this paper we study identifying, locating-dominating and self-identifying codes i...

Cryptococcus neoformans (Cn) is a sporeforming, intracellular pathogenic yeast found in soil and other niches worldwide (1). Inhalation of spores is thus extremely common, allowing Cn to infect ~70% of children in urban environments (2). In most cases Cn infections do not present immediate clinical symptoms; rather, Cn is able to enter a chronic latent state that may last for many years by resi...

The commuting graph of a finite non-abelian group G with center Z(G), denoted by ?c(G), is simple undirected whose vertex set G?Z(G), and two distinct vertices x y are adjacent if only xy=yx. Alwardi et al. (Bulletin, 2011, 36, 49-59) defined the common neighborhood matrix CN(G) energy Ecn(G) G. A called CN-hyperenergetic Ecn(G)>Ecn(Kn), where n=|V(G)| Kn denotes complete on n vertices. Two ...

BACKGROUND AND AIMS The proportion of serum carnosinase (CN-1) recognized by RYSK173 monoclonal antibody negatively correlates with CN-1 activity. We thus hypothesized that the epitope recognized by RYSK173 is accessible only in a catalytically incompetent conformation of the zinc dependent enzyme and we mapped its position in the CN-1 structure. Since patients with kidney failure are often def...