Introduction: Primaquine is one of the essential medicines used to treat malaria due Plasmodium vivax. acts by eradicating hypnozoites in liver, and its effect dependent on drug concentrations target tissue. The present study aimed prepare primaquine nanoparticle formulation using chitosan as carriers improve on-target delivery liver. Methods: Primaquine-loaded nanoparticles were prepared ionic...

this study was done to assess bioequivalence between test and reference formulations of escitalopram oxalate 20 mg in healthy indian male subjects. this single-dose, randomized, open-label, 2-period crossover study was carried out in 12 healthy indian male volunteers aged 18 to 55 years under fasting conditions with a wash out of 14 days.  the subjects were randomly assigned to receive the test...

Fluoxetine drops and marketed fluoxetine capsules had quite the same Cmax (50.25 +/- 4.43 vs 47.55 +/- 5.29 ng/ml), but significantly different AUC0-t (717.27 +/- 71.29 vs 644.91 +/- 78.91 ng/ml/h). Furthermore the drops were characterised by a very early Tmax (4.61 +/- 0.85 hours) with a highly significant difference in comparison to the capsules reference compound (6.72 +/- 1.23 hours). After...

We consider the problem of minimizing the makespan(Cmax) on m identical parallel batch processing machines. The batch processing machine can process up to B jobs simultaneously. The jobs that are processed together form a batch, and all jobs in a batch start and complete at the same time. For a batch of jobs, the processing time of the batch is equal to the largest processing time among the job...

328 words Introduction: 420 words Discussion: 1403 words Abbreviations: AUC, area under the curve; CL, clearance, Cmax, maximum concentration; F, bioavailability; Fa, fraction absorbed; Fg, fraction escaping gut wall elimination; Fh, fraction escaping hepatic elimination; HLM, human liver microsomes; PK, pharmacokinetics, SD, standard deviation; tmax, time to reach Cmax. This article has not be...

Triazolam 0.5 mg was administered to 11 dialysis patients and 11 age, weight and sex matched controls. Peak plasma concentrations (Cmax) were higher in control subjects, but there were no other differences between the groups. When dialysis patients took triazolam with 3600 mg aluminum hydroxide suspension, Cmax and AUC were increased into the range observed in control subjects. It appears that ...

Background: Gold bhasma [Swarnabhasma] is a ancient Ayurvedic medicine used for rejuvenation and longevity. This preliminary attempt to study the bioavailability of this medicine. Objectives: It was aimed estimate comparative gold up five hours after oral dose with four different anupana. Materials methods: In in vivo study, 30 healthy human participants were allocated randomly into groups havi...

the bioavailability of two dipyridamol tablet formulations of (dipyridamole from tolidaru and persantin from boehringer) was compared in 14 healthy male volunteers who received a single dose of 25 mg of the test (t) and the reference (r) products in a randomized balanced 2-way crossover design. plasma samples were obtained over a 16 h interval and dipyridamole concentrations determined by hplc ...

Achieving a peak aminoglycoside concentration (Cmax)/MIC of > or = 10 within 48 h of initiation of therapy for pneumonia caused by gram-negative organisms results in a 90% probability of therapeutic response by day 7. Targeting an MIC of 1 microgram/ml, empirical aminoglycoside loading doses of 348 (25th- to 75th-percentile range, 275 to 432) mg were calculated to obtain a Cmax/MIC of 10 in our...

Event cameras are emerging vision sensors and their advantages suitable for various applications such as autonomous robots. Contrast maximization (CMax), which provides state‐of‐the‐art accuracy on motion estimation using events, may suffer from an overfitting problem called event collapse. Prior works computationally expensive or cannot alleviate the overfitting, undermines benefits of CMax fr...