Background: The pattern of poisoning in Russia may be different from other countries. The study objective was to describe the pattern of poisoning with cardiovascular drugs in a major industrial city in Russia, Yekaterinburg. Methods: This study was part of a larger prospective multi-center study including all acute poisonings in patients older than 15 years of age in the city of Yekaterinburg...

The interactions of compound ZDM-81 with some CNS neurotransmitter systems were studied using in vivo methods to evaluate the interaction dopaminergic (catalepsy, induced haloperidol), adrenergic (clonidine hypothermia), GABAergic (test flumazenil) and serotonergic (5-hydroxytryptophan hyperkinesis) systems. It was shown that is able prolong potentiate effects 5-hydroxytryptophan, reduces catal...

The quality-assured preparation of crushed and diluted preparations for children is a challenge. In this study, multicenter study was conducted to validate the method quality assurance baclofen powder, clonidine hydrocortisone powder prepared from tablets according previously established method. In-hospital were at five medical facilities under different crushing mixing conditions. After storag...

BACKGROUND AND OBJECTIVES Clinical effects and the potential synergism between clonidine, an alpha2-adrenergic agonist, and ropivacaine have not been studied in patients undergoing epidural anesthesia. This research aimed at clinically evaluating clonidine associated to ropivacaine for epidural anesthesia. METHODS Participated in this double-blind study 60 patients of both genders who were di...

The rostral ventrolateral medulla (RVLM) may play an important role in the sympatholytic and hypotensive effects of clonidine. The present study examined which type of presympathetic RVLM neuron is inhibited by clonidine, and whether the adrenergic presympathetic RVLM neurons are essential for clonidine-induced sympathoinhibition. In chloralose-anesthetized and ventilated rats, clonidine (10 mi...

Background. Dextromethorphan is a noncompetitive N-methyl D-aspartate receptor antagonist that is clinically feasible for relieving the opioid withdrawal symptoms. This study compares the efficacy of a combination therapy with dextromethorphan and clonidine to treatment with clonidine alone. Methods and Materials. In this double-blind randomized clinical trial, patients were selected from inpat...

previous in vitro work on rabbit knee joint vessels showed that vasoconstrictor effects of nerve stimulation and administration of α-adrenoceptor agonists were mediated predominantly by α1-adrenoceptors5,9 the present experiments were performed to assess the nature of α-adrenoceptor subtypes within these blood vessels in vivo. dose/response relationships for adrenaline and noradrenaline produce...

The administration of epidural opioids, though effective for producing analgesia, has severe side effects in most patients. It is unknown whether clonidine can effectively replace opioids and cause fewer side effects. We compared, in this randomized trial, the incidence of vomiting and pruritus as well as the analgesic profile of three different combinations of bupivacaine, fentanyl, and clonid...

OBJECTIVE To analyze the trends, demographics, and toxic effects associated with pediatric clonidine hydrochloride exposures reported to poison centers. DESIGN Retrospective. SETTING AND PATIENTS Clonidine-only exposures followed up to known outcome in children younger than 19 years reported to the American Association of Poison Control Center's database from January 1, 1993, through Decemb...