The availability of a minimally invasive patient simple, capable of providing tumor information, represents a valuable clinical tool. The liquid biopsy has the potential to achieve this need. Circulating cell free DNA (ccfDNA), other circulating nucleic acids such as microRNA and circulating tumor cells (CTCs), can be obtained from a peripheral blood sample. Liquid biopsy has been particularly ...

BACKGROUND Circulating nucleic acids (CNAs) offer unique opportunities for early diagnosis of clinical conditions. Here we show that microRNAs, a family of small non-coding regulatory RNAs involved in human development and pathology, are present in bodily fluids and represent new effective biomarkers. METHODS AND RESULTS After developing protocols for extracting and quantifying microRNAs in s...

BACKGROUND Potassium (K+) supplementation of isotonic crystalloid fluids in daily fluid therapy is commonly performed, yet its accuracy in veterinary medicine is undetermined. OBJECTIVE To investigate the accuracy of K+ supplementation in isotonic crystalloid fluids. ANIMALS None. METHODS Observational study. 210 bags of fluid supplemented with KCl being administered to hospitalized dogs ...

introduction  self-efficacy in clinical performance had an important role in applying competencies; also competencies and self-efficacy in clinical performance influenced to quality care of nursing and midwifery students. so the present study aimed to define the relationship between clinical competencies and clinical self-efficacy among nursing and midwifery students. materials and methods  thi...

OBJECTIVE Summarize the current knowledge about oxidative stress-related organ dysfunction in inflammatory and septic conditions, and its potential prevention and treatment by antioxidants in critically ill patients, focusing on naturally occurring antioxidants and clinical trials. STUDY SELECTION PubMed, MEDLINE, and personal database search. SYNTHESIS Plasma concentrations of antioxidant ...

We are very excited to present to you this issue of “Anae­ sthe siology and Intensive Therapy” (AIT) containing the Proceedings of the Fourth International Fluid Academy Days (iFAD) with some excellent reviews from internationally renowned experts in their field! This 4th iFAD will deliver once more a compact two­day programme on clinical fluid management, a topic that has been neglected for a ...

IMPORTANCE Use of hypotonic intravenous fluids for maintenance requirements is associated with increased risk of hyponatremia that results in morbidity and mortality in children. Clinical trial data comparing isotonic and hypotonic maintenance fluids in nonsurgical hospitalized pediatric patients outside intensive care units are lacking. OBJECTIVE To compare isotonic (sodium chloride, 0.9%, a...

This paper investigates the axial unsteady flow of a generalized Burgers’ fluid with fractional constitutive equation in a circular micro-tube, in presence of a time-dependent pressure gradient and an electric field parallel to flow direction and a magnetic field perpendicular on the flow direction. The mathematical model used in this work is based on a time-nonlocal constitutive equation for s...

BACKGROUND Trauma/retrieval patients are often in shock and hypothermic. Treatment of such patients usually involves restoring their blood volume with transfusion of blood (stored at 2 degrees C - 6 degrees C) and/or crystalloids or colloids (stored at ambient temperature). Rapid infusion of these cold fluids can worsen or even induce hypothermia in these patients. Warming of intravenous fluids...