1. The clearance of isotopically labelled sodium diatrizoate by haemodialysis was measured in vitro, with simulated extracellular fluid, and in vivo in eleven patients, at varying rates of fluid or plasma flow. Clearance was also measured in five patients undergoing peritoneal dialysis. In all instances simultaneous measurements of urea clearance were made and the diatrizoate/urea clearance rat...

Objective(s) The purpose of this study was assessment of the influence of acute manic phase on the steady state pharmacokinetics of valproic acid (VPA) in bipolar patients in comparison with those of epileptic patients. Materials and Methods Ninteen acutely manic and 25 epileptic patients who fulfilled inclusion and exclusion criteria were entered in this prospective study. Blood samples were...

Three piece bogies are widely in use by the freight railway services throughout the world. In comparison with the other freight bogies they cost less and are easier to maintain. However, they do not exhibit favorable curving behavior. Amongst the methods to improve the bogie performance is the proposal to introduce lateral clearance in the bogies’ axleboxs. In the case of the three piece bogies...

Fetal metabolism significantly contributes to the clearance of drugs from the fetus. To understand how the changes in fetal metabolism expected in late gestation alter fetal drug clearance, serial measurements of morphine metabolism were made in the fetal baboon over the latter third of gestation. Clearance and metabolism were evaluated in the context of fetal growth, onset of labor, and the ad...

A decline in renal function suggests progression of chronic kidney disease. This can be determined by measured GFR (e.g., iothalamate clearance), serum creatinine (SCr)-based GFR estimates, or creatinine clearance. A cohort of 234 patients with autosomal dominant polycystic kidney disease and baseline creatinine clearance>70 ml/min were followed annually for four visits. Iothalamate clearance, ...

An extremely rapid blood clearance rate of murine IgG2a antibodies was found in all strains tested of outbred Swiss nu/nu mice, including mice from the major commercial suppliers. The clearance half-life was less than 5 h, in comparison to a 4-5-day half-life in BALB/c mice. Therefore, most of the IgG2a antibody injected i.v. in such mice is cleared before it can reach interstitial fluid, which...

OBJECTIVE To correlate lactate clearance with Pediatric Intensive Care Unit (PICU) mortality. METHODS 45 (mean age 40.15 mo, 60% males) consecutive admissions in the PICU were enrolled between May 2012 to June 2013. Lactate clearance (Lactate level at admission - level 6 hr later x 100 / lactate level at admission) in first 6 hours of hospitalization was correlated to in-hospital mortality an...

kermanshah province is the main producer of various chickpea cultivars in iran. in this study a laboratory peg-tooth thresher was employed for chickpea threshing. the effect of cylinder speed (9, 12, 15 m/s), concave clearance (12, 14, 16 mm), feed rate (80, 160, 240 kg/h) and material moisture content (5, 10, 15% w.b.) was studied on percentage of grain damage, threshing efficiency and percent...

1. The renal clearance of oxalate was studied in six normal subjects and in two patients with primary hyperoxaluria utilizing a constant infusion of [14C]oxalic acid. 2. The [14C]oxalate clearance in normal subjects was between 101 and 217 ml/min with a range in the ratio ofp4C]oxalate clearance to creatinine clearance of 1,33-2,09. 3. The oxalate clearance in two patients with primary hyperoxa...