Hyperolactone C is prepared from furan 4. The key transformation is a tandem Claisen rearrangement/lactonization.

A novel and stereo-controlled method for the preparation of functionalized macrolactams was developed. The process involves stereoselective enol ether formation, followed by an azacyclic ring expansion via an aza-Claisen rearrangement. Herewith, we describe a systematic investigation of an aza-Claisen rearrangement-induced ring expansion of azacycles prepared by appending E/Z-enol ethers to the...

The tetranortriterpene cipadonoid B was efficiently constructed from synthetic azedaralide in a one-pot cascade, via the underutilised ketal-Claisen rearrangement.

In a study of articles published in the Proceedings of the National Academy of Sciences, Gunther Eysenbach discovered a significant citation advantage for those articles made freely-available upon publication (Eysenbach 2006). While the author attempted to control for confounding factors that may have explained the citation differential, the study was unable to control for characteristics of th...

Abstract Polarized alkynes such as ynol ethers and ynamides have attracted much attention due to their inherent unique reactivity. Herein, we report Au(I)-catalyzed hydroalkoxylation/Claisen rearrangement cascade reactions of aryl with allylic alcohols. At the first stage (hydroalkoxylation) this reaction, attack alcohols or occurs at ?-position polarized in a completely regioselective manner. ...

Unsaturated epsilon-lactones bearing an alpha-arylsulfonyl or alpha-arylsulfoximinyl substituent undergo stereoselective transannular, decarboxylative Claisen rearrangement to give substituted vinylcyclopropanes.