All prior drug development programs of neuroprotective agents were unsuccessful for a variety of reasons related to both preclinical assessment and the design/implementation of clinical trials. The neuroprotection hypothesis of improving functional outcome related to salvaging ischemic brain tissue is strongly supported by robust preclinical data for many agents. In the future, monotherapy neur...

Despite global and regional health crises, global life expectancy has increased continuously and substantially over the past 40 years. This is associated with an increase in incidence of age-related diseases, such as ischemic stroke and has an important socio-economic impact. There is a growing demandto have more effective treatments to reduce disability and improve the outcome of stroke patien...

Sir, We read with great interest the comment of Dr Grieb that two independent groups previously investigated the effects of CDP-choline (citicoline) on the course of EAE in Lewis rats and found beneficial effects of the substance. The results were presented at scientific meetings by Clayton et al. (1999) and Grieb et al. (2004). However, the results were not published as research papers and thu...