Humans exhibit substantial inter-individual differences in pain perception, which contributes to variability in analgesic efficacy. Individual differences in pain sensitivity have been linked with variation in the serotonin transporter gene (5-HTTLPR), and selective serotonin reuptake inhibitors (SSRIs) such as citalopram have been increasingly used as treatments for multiple pain conditions. W...

BACKGROUND Patients with mixed anxiety-depressive disorder (MADD) suffer both anxiety and depression. Antidepressants, especially, selective serotonin reuptake inhibitors are among agents of choice for treating this condition. OBJECTIVES This study compared the efficacy of Cipram® with its generic, citalopram. PATIENTS AND METHODS Forty adult outpatients (between 18 to 55 years of age) with...

objective: hypoglycemia with multiple etiologies is a common in diabetic patients. the current study describes the probability of interaction between maprotiline, selective serotonine reuptake inhibitors like citalopram for induction of hypoglycemia. case presentation: a 47 year-old diabetic woman used tablet citalopram 20mg daily because of generalized anxiety disorder from two years ago, but ...

background: although plenty of medications have shown promise in the treatment of irritable bowel syndrome (ibs), none have relieved all complaints adequately to be considered as gold standard. based on previous data regarding the effectiveness of olanzapine in other functional or psychosomatic disorders and clinical experience of the authors on its efficacy and safety, we considered to test th...

OVERVIEW Many changes and therapeutic advances have occurred in the treatment of depression in recent years, most notably the availability of the selective serotonin reuptake inhibitor (SSRI) class of agents, followed by the introduction of escitalopram oxalate (LexaproTM, Forest), the first agent in what is known as the “second generation” of SSRIs. However, because of the higher acquisition c...

various studies suggest that selective serotonin reuptake inhibitors (ssris) may be useful in treating pathological skin picking (psp). this study sought to assess effectiveness of citalopram in comparison with placebo in treating psp. forty five individuals with psp were recruited in a four-week, randomized clinical trial of citalopram (20 mg/day) in comparison with placebo. study measures ass...

Depression is a serious health issue and, being such, treatment for it has become topic of increasing concern. Consequently, the prescription rates antidepressants have increased by about 50% over past decade. Among antidepressants, citalopram and venlafaxine are most frequently prescribed in Germany. Due to high consumption low elimination both during wastewater purification, they found surfac...

as the most common male sexual disorder premature ejaculation (pe), also referred to as early ejaculation (ee) or rapid ejaculation (re), affects 30%-40% of sexually active men. despite the limited number of available studies comparing the efficacy of selective serotonin re-uptake inhibitors (ssri) they have been thought to have beneficial effects for the treatment of patients with pe. in the p...

Stimulation of the trigeminal nerve evokes a dramatic decrease in heart rate and blood pressure, and this reflex has generally been termed the trigeminocardiac reflex. A subset of the trigeminocardiac reflex is the diving reflex in which the nasal mucosa is stimulated with water or air-borne chemical irritants. Activation of the diving reflex evokes a pronounced bradycardia, mediated by increas...