background: this study provided the theoretical basis for program development through a new conceptualization of the concept of family physician related health care. methods: critical interpretive synthesis (cis) was used to carry out qualitative analysis and synthesis of the literature from 2006 until 2015. at the beginning of cis, the search strategy was designed to access electronic database...

amyloid-β (aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in alzheimer’s disease pathology.uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Dinuclear and polymer complexes of 4-phenylpyridine (4-phpy), pyazine (pyz), 4,4′-bipyridine (4,4′-bpy) were prepared by using cis-[Rh2(4-Me-pf)2(O2CR)2] (4-Me-pf- =N,N’-bis(4-methylphenyl)formamidinate anion; R = CF3 CMe3) as precursor dinuclear units. The structures cis-[Rh2II,II(4-Me-pf)2(O2CR)2(4-phpy)2] cis-[Rh2II,III(4-Me-pf)2(O2CCMe3)2(4-phpy)2]BF4 [Rh2II,II(4-Me-pf)2(O2CR)2(L)]n (L pyz ...

Fenestranes are an intriguing class of highly strained molecules possessing a quaternary carbon with bonds that deviate from the canonical tetrahedral geometry. Herein we report the discovery that the natural product pleuromutilin can be used as a structurally complex starting material for the synthesis of a series of bridged cis,cis,cis,cis-[4.5.5.5]- and cis,cis,cis,cis-[4.5.7.5]oxafenestrane...

Cochlear implants (CIs) represent a significant engineering and medical milestone in the treatment of hearing loss for both adults children. In this review, we provide brief overview CI technology, describe benefits that CIs can to children who receive them, discuss specific limitations issues faced by users. We emphasize relevance linguistics community demonstrating how successfully access spo...

The employment of culture and language as a Chinese foreign policy strategy combines the leadership’s ideas academic effort to communicate with world. China’s approaches disseminating cultural soft power are seen through overseas Confucius Institutes (CIs). CIs have been recognized symbol for transmitting elements abroad. This research argues that function agents Beijing by promoting culture, f...

Tagetes is a genus of 56 species of annual and perennial mostly herbaceous plants in the sunflower family (Asteraceae or Compositae).In this research our goal was recognizing the main components of the plant to extract useful ones. Essential oils of the leaves, seeds and flowers of Tagets minuta L., growing wild in Iran, were extracted by hydrodistillation an...