نتایج جستجو برای: cigarette smoke extracts cse

تعداد نتایج: 177106  

2015
LI ZHANG XIALING GUO WANG XIE YUPING LI MIAO MA TING YUAN BAILING LUO

Cigarette smoke can cause endoplasmic reticulum stress and induce apoptosis, both of which are important pathogenic factors contributing to chronic obstructive pulmonary disease. The aim of the present study was to produce a cigarette smoke extract (CSE)‑induced apoptosis human bronchial epithelial cell (HBEpC) model, to investigate the protective effects of resveratrol (RES). The role of oxyge...

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2018
Serena Di Vincenzo Irene H Heijink Jacobien A Noordhoek Chiara Cipollina Liboria Siena Andreina Bruno Maria Ferraro Dirkje S Postma Mark Gjomarkaj Elisabetta Pace

Inflammation and ageing are intertwined in chronic obstructive pulmonary disease (COPD). The histone deacetylase SIRT1 and the related activation of FoxO3 protect from ageing and regulate inflammation. The role of SIRT1/FoxO3 in COPD is largely unknown. This study evaluated whether cigarette smoke, by modulating the SIRT1/FoxO3 axis, affects airway epithelial pro-inflammatory responses. Human b...

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2011
Shin Myung Kang Jin Young Yoon Yu Jin Kim Sang Pyo Lee Sung Hwan Jeong Jeong-Woong Park

Background: It is known that cigarette smoke (CS) causes cell death. Apoptotic cell death is involved in the pathogenesis of CS-related lung diseases. Some members of the protein kinase C (PKC) family have roles in cigarette smoke extract (CSE)-induced apoptosis. This study was conducted to investigate the role of PKC epsilon in CSE-induced apoptosis in human lung fibroblast cell line, MRC-5. M...

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Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2013
Yue Zhao Yuan Xu Yuan Li Wenchao Xu Fei Luo Bairu Wang Ying Pang Quanyong Xiang Jianwei Zhou Xinru Wang Qizhan Liu

Cigarette smoking constitutes a major human health hazard because it is the most important risk factor for lung cancer. Although evidence for smoking-induced lung cancer in humans is strong, the molecular mechanisms by which smoking causes cancer remain to be established. In this investigation, we evaluated the roles of inflammation and the epithelial-mesenchymal transition (EMT) in cigarette s...

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2011
Beata Kosmider Elise M. Messier Hong Wei Chu Robert J. Mason

BACKGROUND Cigarette smoke (CS) is a highly complex mixture and many of its components are known carcinogens, mutagens, and other toxic substances. CS induces oxidative stress and cell death, and this cell toxicity plays a key role in the pathogenesis of several pulmonary diseases. METHODOLOGY/PRINCIPAL FINDINGS We studied the effect of cigarette smoke extract (CSE) in human alveolar epitheli...

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2010
Hao Fan Libuse A. Bobek

OBJECTIVE The human MUC7 gene encodes a low-molecular-weight mucin glycoprotein that functions in lubrication/protection of epithelial surfaces of the oral cavity and respiratory tract. This study was designed to evaluate the effect of cigarette smoke extract (CSE), cigarette smoke (CS), and Pseudomonas aeruginosa lipopolysaccharide (LPS), either alone or in the combination, on MUC7 expression ...

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2013
Yuta Takahashi Shizuyo Horiyama Yoko Kimoto Noriko Yoshikawa Masaru Kunitomo Satomi Kagota Kazumasa Shinozuka Kazuki Nakamura

We investigated the effect of a nicotineand tar-free cigarette smoke extract (CSE) using an experimental metastasis mouse model which was intravenously injected with B16-BL6 mouse melanoma cells. Three-hour pretreatment of cells with various concentrations of CSE (0%, 0.1%, 0.3%, and 1%) dose-dependently reduced the number of lung metastatic nodules 14 days after tumor injection. To elucidate t...

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Journal: :American journal of physiology. Lung cellular and molecular physiology 2013
Hiromichi Hara Jun Araya Saburo Ito Kenji Kobayashi Naoki Takasaka Yutaka Yoshii Hiroshi Wakui Jun Kojima Kenichiro Shimizu Takanori Numata Makoto Kawaishi Noriki Kamiya Makoto Odaka Toshiaki Morikawa Yumi Kaneko Katsutoshi Nakayama Kazuyoshi Kuwano

Mitochondria are dynamic organelles that continuously change their shape through fission and fusion. Disruption of mitochondrial dynamics is involved in disease pathology through excessive reactive oxygen species (ROS) production. Accelerated cellular senescence resulting from cigarette smoke exposure with excessive ROS production has been implicated in the pathogenesis of chronic obstructive p...

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Journal: :Journal of immunology 2012
Fen-Fen Li Jian Shen Hui-Juan Shen Xue Zhang Rui Cao Yun Zhang Qiu Qui Xi-Xi Lin Yi-Cheng Xie Lin-Hui Zhang Yong-Liang Jia Xin-Wei Dong Jun-Xia Jiang Meng-Jing Bao Shanshan Zhang Wen-Jiang Ma Xi-Mei Wu Huahao Shen Qiang-Min Xie Yuehai Ke

Cigarette smoke (CS), the major cause of chronic obstructive pulmonary disease, contains a variety of oxidative components that were implicated in the regulation of Src homology domain 2-containing protein tyrosine phosphatase 2 (Shp2) activity. However, the contribution of Shp2 enzyme to chronic obstructive pulmonary disease pathogenesis remains unclear. We investigated the role of Shp2 enzyme...

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2016
Dong Wu Yalian Yuan Zhixiu Lin Tianwen Lai Min Chen Wen Li Quanchao Lv Binfan Yuan Dongmin Li Bin Wu

Etiological evidence demonstrates that there is a significant association between cigarette smoking and chronic airway inflammatory disease. Abnormal expression of placental growth factor (PlGF) has been reported in COPD, and its downstream signaling molecules have been reported to contribute to the pathogenesis of airway epithelial cell apoptosis and emphysema. However, the signaling mechanism...

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