OBJECTIVE To review the current evidence on the mechanism of actions and clinical applications of maggot debridement therapy. DATA SOURCES Literature search of PubMed and Medline was performed up to January 2007. STUDY SELECTION Original and major review articles related to maggot debridement therapy were reviewed. Key words used in the literature search were 'maggot debridement therapy', '...

The treatment of chronic wounds, burns and scars is not easy to solve, because the most suitable dressing for wound care depends not only on the type of wound but also on the stage of the healing process. Wound dressing have been employed to speed up the healing process in acute and chronic wounds by keeping healing tissues moist and increasing superficial wound epithelialization [1,2]. Apart o...

Adipose tissue-derived stem cells (ADSCs) hold great potential for the stem cell-based therapy of cutaneous wound healing. Stromal cell-derived factor-1 (SDF-1) activates CXC chemokine receptor (CXCR)4+ and CXCR7+ cells and plays an important role in wound healing. Increasing evidence suggests a critical role for SDF-1 in cell apoptosis and the survival of mesenchymal stem cells. However, the f...

Chronic wound (CW) treatment by large is a burden for the government and society due to its high cost and time consuming treatment. It becomes more serious for the old age patient with the lack of moving flexibility. Proper wound recovery management is needed to resolve this problem. Careful and accurate documentation is required for identifying the patient’s improvement and or deterioration ti...

BACKGROUND A chronic wound is a wound that is arrested in the inflammatory phase of wound healing and cannot progress further. Over 90% of chronic wounds contain bacteria and fungi living within a biofilm construct. THE PROBLEM Each aggregation of microbes creates a distinct biofilm with differing characteristics so that a clinical approach has to be tailored to the specifics of a given biofi...

A chronic wound is defined as one that does not heal in an orderly sequence or predictable timeframe and fails to progress along the wound-healing continuum. In the UK alone, there were recently estimated to be 1.3 million chronic wounds, of which 153,000 were pressure ulcers, 253,000 dehisced surgical wounds, 169,000 diabetic foot ulcers and 730,000 leg ulcers (Guest et al, 2015). A leg ulcer ...