BACKGROUND The tendency to respond with fear and avoidance can be seen as a shared vulnerability contributing to the development of post-traumatic stress disorder (PTSD) and chronic pain. Although several studies have examined which specific symptoms of PTSD (re-experiencing, avoidance, emotional numbing and hyperarousal) are associated with chronic pain, none has considered this association wi...

introduction: low back pain is the most common musculoskeletal complication. although there are many ways to treat low back pain, achieving a concise, simple, and compact method is required in today's industrial societies. the purpose of this study was to evaluate the effect of six weeks selected core stabilization exercises on pain and functional disability in patients with nonspecific chronic...

background: phantom limb pain (plp) is approximately a common condition after limb amputation, which potentially affects the quality of life. we aimed to evaluate anxiety and depression in patients with amputated limbs suffering from plp and to compare these psychological dysfunctions with that of patients with non‑phantom chronic pain. methods: a total number of 16 male amputees with plp and 2...

aim and background: psychological factors have a pivotal role in the chronicity of diseases. chronic pain may lead to depression and disabilities in patients, which may change their quality of life and life style. the aim of this study was to evaluate the relationship between coping strategies, depression, physical disability, and pain intensity in people with chronic back pain. method and mate...

Medulloblastoma, the most common brain tumor in childhood, appears to originate from cerebellar granule cell precursors (GCPs), located in the external granular layer (EGL) of the cerebellum. The antiproliferative gene PC3 (Tis21/BTG2) promotes cerebellar neurogenesis by inducing GCPs to shift from proliferation to differentiation. To assess whether PC3 can prevent the neoplastic transformation...

We have previously shown that mice with a CNS restricted knock-out of the integrin beta1 subunit gene (Itgb1-CNSko mice) have defects in the formation of lamina and folia in the cerebral and cerebellar cortices that are caused by disruption of the cortical marginal zones. Cortical structures in postnatal and adult Itgb1-CNSko animals are also reduced in size, but the mechanism that causes the s...

The Chain Pair Simplification problem (CPS) was posed by Bereg et al. who were motivated by the problem of efficiently computing and visualizing the structural resemblance between a pair of protein backbones. In this problem, given two polygonal chains of lengths n and m, the goal is to simplify both of them simultaneously, so that the lengths of the resulting simplifications as well as the dis...

The aim of this paper is to discuss the results of a review into the literature related to chronic pain and the older adult. Several themes within the review have been identified and reported elsewhere and the final report has been published by the University of Sheffield in the form of an annotated bibliography. This report focuses upon the findings of the in relation to the assessment of pain...

Greig cephalopolysyndactyly syndrome (GCPS) is an autosomal dominant disorder with polydactyly and syndactyly of the limbs and a broad spectrum of craniofacial abnormalities. Craniosynostosis of the metopic suture (interfrontal suture in mice) is an important but rare feature associated with GCPS. GCPS is caused by mutations in the transcription factor GLI3, which regulates Hedgehog signaling. ...

Background – Chronic low back pain is a complex condition produced by multiple factors. This study investigated the psychological aspects of low back pain in a group of patients. Methods – A total of 112 subjects participated in the study. Fifty-six patients (21 females and 35 males) had low back pain and were seeking treatment in two clinics. A control group of 56 subjects (20 females and 36 m...