OBJECTIVE To establish diagnostic criteria for acute mountain sickness (AMS) in preverbal children. DESIGN Nonrandomized control trial. SETTING Ambulatory. PARTICIPANTS Children aged 3 through 36 months and adults from the Denver, Colo, area (altitude, 1610 m). MAIN OUTCOME MEASURES The Lake Louise Scoring System was modified, using a fussiness score as the headache equivalent and a ped...

The rapid ascent to 4560 m caused minor symptoms of acute mountain sickness such as headache, nausea, and insomnia in all participants. We did not, however, find any influence of this short term exposure to high altitude on the morphology of the red cells. Our results are in contrast to the morphological changes observed by Rowles and Williams at a similar altitude (4600 m) during an expedition...

Low pressure, low oxygen concentration, and intense ultraviolet (UV) radiation in high-altitude environments, can cause oxidative stress which can trigger mountain sickness. A recent study demonstrated that hydrogen gas with a good permeability in biological membranes can treat various disorders by exerting its selective anti-oxidation and anti-inflammatory effects, indicating that hydrogen the...

Many high mountaineers die of acute mountain sickness in the high mountains of Nepal during their adventure. Most of them administer acetaminophen (AP) as an analgesic. Various cells with higher expression of cytochrome P-450 (CYP) would metabolize AP and lead to cellular impairment. CYP is a major enzyme system in the metabolism of xenobiotics in different organs of the human being including i...

The response of serum angiotensin converting enzyme (ACE) activity to three grades of hypoxia was studied in two groups of human subjects. Hypoxic gas mixtures having oxygen concentrations of 14, 12.6 and 10.4% were breathed successively for a period of 10 min at each concentration. Venous blood was sampled at the end of each of the three periods and arterial oxygen saturation was recorded thro...