The main mechanism for the occurrence of urticaria is degranulation mast cells. It has been proven that, regardless activation pathway, clinical manifestations will not differ. According to literature, up half cases chronic spontaneous are autoimmune in nature, can be combined with thyroid disease, SLE, etc., and have a more severe course. In therapy, antihistamines traditionally used. However,...

Chronic spontaneous urticaria is an itching skin disease characterised by wheals, angioedema, or both present for more than six weeks. Omalizumab is a humanized anti-IgE monoclonal antibody recently approved for treatment of chronic urticaria. Several randomised controlled trials have investigated the safety, tolerability, and efficacy of omalizumab for chronic urticaria. The safety of omalizum...

PURPOSE Although coagulation activation has been reported in chronic urticaria, data pertaining to detailed changes in coagulation factors and global coagulation status are lacking. The current study evaluated global coagulation status in patients with chronic urticaria using thrombin generation assay (TGA) and the levels of individual coagulation factors. METHODS Patients with chronic urtica...

BACKGROUND It has been demonstrated that neutrophils, eosinophils and monocytes, under appropriated stimulus, may express tissue factor and therefore, activate the extrinsic pathway of coagulation. We performed a transversal and case-control study of patients with chronic urticaria and patients with psoriasis, in our outpatient clinic to evaluate the production of D-dimer. OBJECTIVE To evalua...

INTRODUCTION The association of chronic urticaria and thyroid autoimmunity is not well recognised and the potential use of thyroxine in the treatment of chronic urticaria in patients with thyroid autoimmunity is even less well known. CLINICAL PICTURE We report a case of chronic urticaria in an euthyroid patient with evidence of significantly elevated levels of thyroglobulin and microsomal ant...

BACKGROUND Chronic urticaria affects patients by interfering with their daily activities, damaging their self-esteem and negatively affecting their interpersonal relationships. Healthcare professionals may underestimate the impact of the condition on patients' quality of life. OBJECTIVES To evaluate quality of life using one generic and one disease-specific health-related quality of life inst...

BACKGROUND An association between class I and II alleles of the major histocompatibility complex and idiopathic chronic urticaria has previously been observed in different populations, but there are still no studies on Brazilian populations in this regard. OBJECTIVE The involvement of the major histocompatibility complex classes I and II (loci A, B and DR) in Brazilian patients with idiopathi...

BACKGROUND: Chronic urticaria is a skin disease characterized by the appearance of itchy weals and/or angioedema for 6 or more weeks. subdivided into chronic spontaneous urticaria, which occurs due to an unknown cause, and inducible as result exposure various physical factors (water, cold, heat, pressure, mechanical irritation), can occur simultaneously independently each other. Omalizumab, ant...

This evidence- and consensus-based guideline was developed following the methods recommended by Cochrane Grading of Recommendations Assessment, Development Evaluation (GRADE) working group. The conference held on 1 December 2016. It is a joint initiative Dermatology Section European Academy Allergology Clinical Immunology (EAACI), EU-founded network excellence, Global Allergy Asthma Network (GA...