Seven years' experience in prenatal screening for fetal chromosome aberrations in the west of Scotland is reviewed. Fetal chromosome analysis was undertaken in 716 pregnancies, 49% of which were judged to be at substantial risk of a fetal chromosome aberration. A chromosome aberration was found in 26 pregnancies, 14 of which were sufficiently severe to justify termination: the latter included n...

Effects of gamma irradiation on the worm survival and chromosomal aberration of Clonorchis sinensis were studied. The metacercariae irradiated with various amounts of gamma radiation (ranging from 5 Gy to 50 Gy) were fed to rats, and the effects were compared with those of non-irradiated controls. Recovery rates of adult worms in irradiated groups were reduced gradually as increasing of the irr...

introduction: fluorscence in situ hybridization (fish) enables specific detection of unique sequences of varying length, chromosomal regions or entire chromosomes within metaphase or interphase cells. recent developments in this technology permit the rapid mapping and ordering of dna fragments on single metaphase chromosome bands. the technique of fish incorporates several stages including: pro...

To examine whether biomarkers such as sister chromatid exchanges (SCEs) and chromosome aberrations (CAs) can predict cancer development, a nested case-control study was performed in a blackfoot endemic area with a known high cancer risk. A cohort of 686 residents was recruited from three villages in the blackfoot endemic area. Personal characteristics were collected, and venous blood was drawn ...

BACKGROUND Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up ...

purpose: to investigate the relationship between higher-order aberrations (hoas) and contrast sensitivity function (csf) in myopes. methods: in this cross-sectional study, hoas and csf were measured in myopic eyes over a 6-mm pupil. pupil diameter was measured in photopic condition. the correlation between hoas and csf was investigated using multivariate linear regression analysis. results: sev...

Down’s syndrome (DS) is the most frequent chromosomal aberration among newborns, with an incidence of 1/660 live births; trisomy 21 occurs in 95% of cases due to maternal meiosis I non-disjunction, resulting in three full copies of chromosome 21 in each cell. Of these cases, 4% are due to parental/de novo translocation and 1% is due to mosaicism. Frequency of congenital heart defects (CHDs) in ...