Triple-negative breast cancer (TNBC), a biologically diverse subtype of cancer, is associated with poor prognosis. Patients (pts) TNBC who achieve pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) have improved disease free and overall survival. We investigated whether early circulating tumor DNA (ctDNA) measurements could predict to NAC. ctDNA was detected in 94 serial pl...

the autism spectrum disorders (asds) are common neurodevelopmental disorders estimated to affect 1 in 88 children. asd is a complex condition, result of genetic, epigenetic and environmental factors. however, genetic comopnent seems to play an important role. the loss/gain of 1kb and more nucleotides, copy number variation (cnv), is the significant genetic factor in the etiology of asd. the cnv...

The Sylow theorems hold for finite extra loops, as does P. Hall’s theorem for finite solvable extra loops. Every finite nonassociative extra loop Q has a nontrivial center, Z(Q). Furthermore, Q/Z(Q) is a group whenever |Q| < 512. Loop extensions are used to construct an infinite nonassociative extra loop with a trivial center and a nonassociative extra loop Q of order 512 such that Q/Z(Q) is no...

The noble gases are the most inert group of the periodic table, but their reactivity increases with pressure. Diamond-anvil-cell experiments and ab initio modelling have been used to investigate a possible direct reaction between xenon and oxygen at high pressures. We have now synthesized two oxides below 100 GPa (Xe2O5 under oxygen-rich conditions, and Xe3O2 under oxygen-poor conditions), whic...

This paper presents a printed near field communication system that can be integrated into everyday objects, like paper products or plastic parts. The interface is realised by high-volume production technologies, like printing and injection moulding, as they allow for the integration of “low-end” electronics at low costs and, thus, potentially enable a wide spreading of the technology. As a firs...

2008. Is spread of invasive species regulated? Using ecological theory to interpret statistical analysis. Appendix A. Technical note on testing random walk hypotheses, derivation of dynamics under "spread regulation" of new-site ratios, models used for simulated spread scenarios, and mathematical approximation showing approximate "spread regulation" expected slope of-1. A1. Statistical testing ...

Noninvasive measurements of regional cerebral blood flow (rCBF), using the Xe-133 clearance technique and a two-compartment open model for data analysis, may produce false numerical results when distinction between compartments is poor. For rapid detection of error conditions of that kind, we propose a three-dimensional graphic display of the quality of fit to the original clearance curve, base...