The analysis of complex samples is facilitated by the emergence two-dimensional liquid chromatography. Despite optimization efforts to reach tremendous peak capacities, separation neutral compounds remains limited. Indeed, most combinations chromatographic modes suffer either from a lack orthogonality or serious solvent incompatibilities. involving combination chromatography and supercritical f...

Supercritical fluid and microbore liquid chromatography offer potential applications for drug analysis. In supercritical fluid chromatography (SFC), the mobile phase is a gas (e.g., carbon dioxide) maintained at its supercritical state--that is, above its critical temperature and pressure, above which it cannot be liquefied even with further increases in applied pressure. The SFC mobile phase h...