We report the case of a 35-year-old homeless alcoholic and illicit drug user, with AIDS, who was admitted to the emergency unit complaining of asthenia and a weight loss of 30 kg over the preceding three months. Clinical and laboratory data confirmed a diagnosis of marasmus, bacterial pneumonia, chorioretinitis caused by Toxoplasma gondii and oral Candida infection. The patient also presented l...

A case of a female patient with local and systemic complications of metallosis, following catastrophic wear of a revised hip arthroplasty, is presented. The patient had a history of a fractured ceramic-on-ceramic implant, exchanged with a metal-on-polyethylene prosthesis. Systemic complications included sarcoidosis-like reactions, presenting as granulomatous lung disease, along with chorioretin...

BACKGROUND Ocular syphilis is often difficult to diagnose because of the wide variation in clinical features.HIV co-infection may further complicate the picture. CASE PRESENTATION Herein the authors report an unusual primary syphilitic ocular lesion in a 45-year-old Italian HIV-infected bisexual man who presented with a unilateral eyelid lesion. Associated precocious signs and symptoms in the...

Zika virus (ZIKV) is an important pathogen that causes not only neurologic, but also ocular, abnormalities. Thus, it is imperative that models to study ZIKV pathogenesis in the eye are developed to identify potential targets for interventions. Here, we studied ZIKV interactions with human retinal cells and evaluated ZIKV's pathobiology in mouse eyes. We showed that cells lining the blood-retina...

BACKGROUND To describe the clinical manifestations and ancillary examination outcomes of ocular syphilis in Southeast China. MATERIALS AND METHODS This is a retrospective, nonrandom case study. Demographic information, serum and cerebrospinal fluid (CSF) test results, and findings of fundus fluorescein angiography (FFA), indocyanine green angiography (ICGA), and spectral domain optical cohere...

Case presentation: A 3 month-old boy with fever and new episodes of seizures was admitted from another institution in an ongoing tuberculosis investigation substantiated by central nervous system imaging. The patient evolved recurrence fluctuating consciousness. Ophthalmology exam revealed chorioretinitis. Neural axis abnormalities on magnetic resonance imaging were described signs diffuse meni...

Toxoplasmosis is a zoonotic protozoal disease caused by the intracellular parasite Toxoplasma gondii and characterized polymorphism of clinical symptoms with predominant involvement nervous, lymphatic systems, eyes, skeletal muscles myocardium. Despite variety therapeutic agents, treatment toxoplasmosis remains problematic requires an interdisciplinary approach. Complete release toxoplasmas fro...