Zika virus (ZIKV) is an important pathogen that causes not only neurologic, but also ocular, abnormalities. Thus, it is imperative that models to study ZIKV pathogenesis in the eye are developed to identify potential targets for interventions. Here, we studied ZIKV interactions with human retinal cells and evaluated ZIKV's pathobiology in mouse eyes. We showed that cells lining the blood-retina...

Over 100 years ago, Oeller described for the first time the presence of anastomoses between the retinal and choroidal circulations in eyes with disciform scars(1). Later, these were recognized in association with laser photocoagulation(2), radiotherapy(3), chorioretinal inflammatory diseases(4) and parafoveal telangiectasias(5). The interest in this condition even led to anatomopathological stu...

AIM To determine the relation between alterations in the retinal topography and thickness, visual acuity, and retinal pigment epithelium hypopigmentation in atrophic age related macular degeneration (AMD). METHODS 22 patients, mean age 74 (SD 8) years, with atrophic AMD were recruited. An optical imaging system based on the retinal thickness analyser (RTA) was applied to generate a series of ...

BACKGROUND We previously reported an Ser50Thr mutation in the NRL gene as a cause of autosomal dominant retinitis pigmentosa. OBJECTIVE To determine the characteristic features of the autosomal dominant retinitis pigmentosa phenotype associated with the NRL Ser50Thr mutation in affected individuals from 4 related families. METHODS Clinical records were available for 21 affected individuals;...

Achondroplasia is a congenital disorder resulting from a specific disturbance in endochondral bone formation. The ophthalmic features reportedly associated with achondroplasia are telecanthus, exotropia, inferior oblique overaction, angle anomalies and cone-rod dystrophy. This is first report of chorioretinal coloboma in achondroplasia. An 8-year-old female was diagnosed with a developmental de...

Chorioretinal neovascularisation was noted in the midperipheral fundus of a young black girl with sickle cell anaemia. Rapid-sequence fluorescein angiography showed choroidally fed neovascularisation in the centre of a large black sunburst (chorioretinal scar). We suspect that a massive midperipheral retinal haemorrhage from the sickle cell disease caused the sunburst and altered Bruch's membra...

Introduction: Pathological myopia (PM) is defined as the presence of structural changes due to axial elongation in eyes with high myopia. Numerous vision-threatening conditions are known be more prevalent pathological including retinal detachment, myopic retinoschisis, macular holes, choroidal neovascularization, and chorioretinal atrophy. These often lead progressive loss vision. Present study...

OBJECTIVE To determine the incidence of new chorioretinal lesions in patients with congenital toxoplasmosis who were treated throughout their first year of life. DESIGN Prospective longitudinal observation of a cohort. PARTICIPANTS One hundred thirty-two children were studied as part of the longitudinal observation. METHODS One hundred thirty-two children were treated during their first y...